Luo Zhao-Yun, Chen Qiang, Yang Hui, Lin Min, Chen Chan-Yu, Yang Chun, Yang Li-Ye
Central Laboratory, Chaozhou Central Hospital, Chaozhou, Guangdong Province, China E-mail :
Asian Pac J Cancer Prev. 2015;16(14):5675-9. doi: 10.7314/apjcp.2015.16.14.5675.
Low-risk human papillomavirus (LR-HPV) infection is the main cause of genital warts. LR- HPV genotypes 6 and 11 are associated with genital warts, but there have only been a few published studies about the genotype-specific prevalence of HPV in genital warts in China. The objective of our study was to assess the prevalence of HPV genotypes for clinical cases involving both men and women and to evaluate the potential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in eastern Guangdong province of China.
A total of 696 eligible patients with genital warts were enrolled during the period Aug 2009 through Oct 2014. Specimens were collected from genital warts, the HPV GenoArray test was used for HPV detection and genotyping, which could detect 21 HPV genotypes, including genotypes 6, 11, 16, and 18.
Among the 696 cases, 675 samples were successfully genotyped. The median age of patients was 32.1 years (range, 16-67 years). The most prevalent genotypes were HPV-6 (285/675, 42.2%), HPV-11 (265/675, 39.3%), HPV-52 (52/675, 7.7%), HPV-16 (51/675, 7.56%), HPV-81 (50/675, 7.40%) and HPV-58 (37/675, 5.48%). Low-risk genotypes predominated, with a prevalence of 96.59%. The cumulative prevalence of genotypes 6 and 11 was 78.7% (531/675), the cumulative prevalence of genotypes 16 and 18 was 11.6% (78/675), and the cumulative prevalence of genotypes 6, 11, 16, and 18 was 82.5% (557/675).
Our results provide strong evidence that, in eastern Guangdong, different from Western countries, the most prevalent low risk HPV genotypes in patients with genital warts are 6, 11 and 81. The quadrivalent HPV vaccine could prevent 82.5% of genital warts in eastern Guangdong.
低风险人乳头瘤病毒（LR-HPV）感染是尖锐湿疣的主要病因。LR-HPV 6型和11型与尖锐湿疣相关，但关于中国尖锐湿疣患者中HPV基因型特异性患病率的已发表研究较少。我们研究的目的是评估涉及男性和女性临床病例中HPV基因型的患病率，并评估四价（6、11、16和18型）HPV疫苗在中国广东省东部的潜在益处。
2009年8月至2014年10月期间，共纳入696例符合条件的尖锐湿疣患者。从尖锐湿疣处采集标本，采用HPV基因芯片检测法进行HPV检测和基因分型，该方法可检测21种HPV基因型，包括6、11、16和18型。
696例病例中，675份样本成功进行了基因分型。患者的中位年龄为32.1岁（范围16 - 67岁）。最常见的基因型为HPV-6（285/675，42.2%）、HPV-11（265/675，39.3%）、HPV-52（52/675，7.7%）、HPV-16（51/675，7.56%）、HPV-81（50/675，7.40%）和HPV-58（37/675，5.48%）。低风险基因型占主导，患病率为96.59%。6型和11型的累计患病率为78.7%（531/675），16型和18型的累计患病率为11.6%（78/675），6、11、16和18型的累计患病率为82.5%（557/675）。
我们的结果提供了有力证据，在中国广东省东部，与西方国家不同，尖锐湿疣患者中最常见的低风险HPV基因型为6、11和81型。四价HPV疫苗可预防广东省东部82.5%的尖锐湿疣。
