Kubo M, Nakagami T, Yamasaki N, Ito M, Nogami M, Taji S
Chem Pharm Bull (Tokyo). 1989 Dec;37(12):3409-11. doi: 10.1248/cpb.37.3409.
Anti-allergic activities of animal biles and commercially available bile acids were evaluated in experimental allergic disease models. Pig bile exhibited marked preventive effects on the models of delayed-type hypersensitivity (type IV allergy), picryl chloride-induced contact dermatitis (PC-CD) and sheep red blood cells (SRBC)-induced footpad swelling in mice. Fel ursi (dried bear gallbladder) also had an inhibitory effect on PC-CD, whereas ox bile, chicken bile and bile acids had no effect on ether of the models.
在实验性变应性疾病模型中评估了动物胆汁及市售胆汁酸的抗过敏活性。猪胆汁对迟发型超敏反应（IV型变态反应）、苦味酸诱导的接触性皮炎（PC-CD）和绵羊红细胞（SRBC）诱导的小鼠足垫肿胀模型表现出显著的预防作用。熊胆（干燥熊胆）对PC-CD也有抑制作用，而牛胆汁、鸡胆汁和胆汁酸对上述任何一种模型均无作用。
