Elabd Seham, Sabry Ismail
Human Physiology Department, Medical Research Institute, Alexandria University , Alexandria , Egypt.
Zoology Department, Faculty of Science, Alexandria University , Alexandria , Egypt.
Front Endocrinol (Lausanne). 2015 Aug 10;6:121. doi: 10.3389/fendo.2015.00121. eCollection 2015.
Oxytocin (OT), a hormone most commonly associated with labor and lactation, may have a wide variety of physiological and pathological functions, which makes OT and its receptor potential targets for drug therapy. In this review, we highlight the newly discovered metabolic role of OT in diabetes and its complication, such as diabetic osteopathy. OT may have positive metabolic effects; this is based on the change in glucose metabolism, lipid profile, and insulin sensitivity. It may modify glucose uptake and insulin sensitivity both through direct and indirect effects. It may also cause regenerative changes in diabetic pancreatic islet cells. Moreover, it has an anabolic effect on the bone biology. So, the activation of the OT receptor pathway by infusion of OT, OT analogs, or OT agonists may represent a promising approach for the treatment of diabetes and some of its complications, including diabetic osteopathy.
催产素（OT）是一种最常与分娩和泌乳相关的激素，可能具有广泛的生理和病理功能，这使得OT及其受体成为药物治疗的潜在靶点。在本综述中，我们重点介绍了OT在糖尿病及其并发症（如糖尿病性骨病）中最新发现的代谢作用。OT可能具有积极的代谢作用；这是基于葡萄糖代谢、血脂状况和胰岛素敏感性的变化。它可能通过直接和间接作用来改变葡萄糖摄取和胰岛素敏感性。它还可能引起糖尿病胰岛细胞的再生变化。此外，它对骨生物学具有合成代谢作用。因此，通过输注OT、OT类似物或OT激动剂来激活OT受体途径可能是治疗糖尿病及其一些并发症（包括糖尿病性骨病）的一种有前景的方法。
