Belkin Molly R, Schwartz Thomas L
SUNY Upstate Medical University, College of Medicine, Syracuse, NY, USA.
Drugs Context. 2015 Aug 14;4:212286. doi: 10.7573/dic.212286. eCollection 2015.
Clonidine and guanfacine are alpha-2 receptor agonists that decrease sympathetic outflow from the central nervous system. Posttraumatic stress disorder (PTSD) is an anxiety disorder that is theorized to be related to a hyperactive sympathetic nervous system. Currently, the only US Food and Drug Administration (FDA)-approved medications for PTSD are the selective serotonin reuptake inhibitors (SSRIs) sertraline and paroxetine. Sometimes use of the SSRIs may not lead to full remission and symptoms of hyperarousal often persist. This article specifically reviews the literature on alpha-2 receptor agonist use for the treatment of PTSD and concludes that while the evidence base is limited, these agents might be considered useful when SSRIs fail to treat symptoms of agitation and hyperarousal in patients with PTSD.
可乐定和胍法辛是α-2受体激动剂，可减少中枢神经系统的交感神经输出。创伤后应激障碍（PTSD）是一种焦虑症，理论上与交感神经系统过度活跃有关。目前，美国食品药品监督管理局（FDA）唯一批准用于治疗PTSD的药物是选择性5-羟色胺再摄取抑制剂（SSRI）舍曲林和帕罗西汀。有时使用SSRI可能无法实现完全缓解，且过度觉醒症状往往持续存在。本文特别回顾了关于使用α-2受体激动剂治疗PTSD的文献，并得出结论：虽然证据基础有限，但当SSRI无法治疗PTSD患者的激越和过度觉醒症状时，这些药物可能会被认为是有用的。
