Surfaces, Products and Textile Processes Research Group, Textile and Paper Engineering Dept., Technical University of Catalonia (UPC), C/ Colom, 1, 08222, Terrassa, Spain; Biomaterials, Biomechanics and Tissue Engineering Group, Materials Science and Metallurgy Dept., UPC, Av. Diagonal 647, 08028, Barcelona, Spain.
Surfaces, Products and Textile Processes Research Group, Textile and Paper Engineering Dept., Technical University of Catalonia (UPC), C/ Colom, 1, 08222, Terrassa, Spain.
Biomaterials. 2015 Dec;71:132-144. doi: 10.1016/j.biomaterials.2015.08.023. Epub 2015 Aug 19.
Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success.
疝修补术是普通外科中最常见的手术之一，其相关并发症通常与感染等有关。将抗生素加载到手术网片上，以便在腹部疝修补部位局部释放，可以是管理与手术植入物相关感染的一种方法。然而，由于聚丙烯（PP）的低润湿性，药物的加载量受到限制。在这项工作中，等离子体被用于调整 PP 网片的表面性质，以获得氨苄青霉素的高负载量，同时保留未改性样品的所需生物学性质，并赋予它们抗菌活性。结果表明，新的表面化学和改善的润湿性导致抗生素负载增加了 3 倍。随后，通过低压等离子体从四甘醇中沉积了类似 PEG 的干涂层，这允许保持高药物负载，并保持细胞特性，如趋化性、粘附性和形态，与未处理的细胞相同，这些细胞已经显示出长期的临床成功。
