Fernández-Palomeque Carlos, Grau Andres, Perelló Joan, Sanchis Pilar, Isern Bernat, Prieto Rafel M, Costa-Bauzá Antonia, Caldés Onofre J, Bonnin Oriol, Garcia-Raja Ana, Bethencourt Armando, Grases Felix
IdISPa, Hospital Universitario Son Espases, 07120, Palma of Mallorca, Spain.
Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS- IdISPa), University of Balearic Islands, 07122, Palma of Mallorca, Spain.
PLoS One. 2015 Aug 31;10(8):e0136560. doi: 10.1371/journal.pone.0136560. eCollection 2015.
Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (<0.610 μM), intermediate (0.61-1.21 μM), and high (>1.21 μM). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivariate analysis, age, serum phosphorous, leukocytes total count and urinary phytate excretion appeared as independent factors predictive of presence of mitral annulus calcification. There was an inverse correlation between urinary phytate content and mitral annulus calcification in our population of elderly out subjects. These results suggest that consumption of phytate-rich foods may help to prevent cardiovascular calcification evolution.
病理性钙化通常是指软组织中形成羟基磷灰石（磷酸钙）的固体沉积物。过饱和是结晶的热力学驱动力，因此人们认为血液中钙和磷水平升高会增加心血管钙化的风险。然而，有几个因素可以促进或抑制病理性钙化的自然过程。这项横断面研究评估了老年门诊患者尿植酸盐的生理水平与心脏瓣膜钙化之间的关系。对188名老年受试者（平均年龄：68岁）进行了研究。通过超声心动图测量瓣膜钙化。从尿样中测定植酸盐，并获取血液化学、收缩末期容积、伴随疾病、心血管危险因素、药物使用和饮食方面的数据。根据尿植酸盐水平将研究人群分为三个三分位数：低（<0.610 μM）、中（0.61 - 1.21 μM）和高（>1.21 μM）。尿植酸盐水平较高的受试者二尖瓣环钙化较少，患糖尿病和高胆固醇血症的可能性也较小。在多变量分析中，年龄、血清磷、白细胞总数和尿植酸盐排泄量是预测二尖瓣环钙化存在的独立因素。在我们的老年门诊患者人群中，尿植酸盐含量与二尖瓣环钙化之间存在负相关。这些结果表明，食用富含植酸盐的食物可能有助于预防心血管钙化的进展。
