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老年期抑郁症神经生物学研究的方法与初步结果。

Methodology and preliminary results from the neurobiology of late-life depression study.

作者信息

Steffens David C, Manning Kevin J, Wu Rong, Grady James J, Fortinsky Richard H, Tennen Howard A

机构信息

Departments of Psychiatry (DCS, KJM) and Community Medicine and Healthcare (RW, JJG, HAT) the Center on Aging (RHF),University of Connecticut Health Center,263 Farmington Ave,Farmington,Connecticut,USA.

出版信息

Int Psychogeriatr. 2015 Dec;27(12):1987-97. doi: 10.1017/S1041610215001386. Epub 2015 Sep 1.

DOI:10.1017/S1041610215001386
PMID:26323208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4626260/
Abstract

BACKGROUND

We sought to investigate the relationship between neuroticism and depression in an elderly cohort. In this paper, we describe the methods of an National Institute of Mental Health-NIMH-supported study and present findings among the cohort enrolled to date.

METHODS

We used the NEO Personality Inventory to assess neuroticism, and we employed several cognitive neuroscience-based measures to examine emotional control.

RESULTS

Compared with a group of 27 non-depressed older control subjects, 33 older depressed subjects scored higher on measures of state and trait anxiety and neuroticism. On our experimental neuroscience-based measures, depressed subjects endorsed more negative words compared with controls on an emotional characterization test. In addition, we found a significant group-by-congruency effect on an emotional interference test where subjects were asked to identify the face's emotional expression while ignoring the words "fear" or "happy" labeled across the face.

CONCLUSION

Thus, in this preliminary work, we found significant differences in measures of neuroticism and emotional controls among older adults with and without depression.

摘要

背景

我们试图在一个老年队列中研究神经质与抑郁之间的关系。在本文中,我们描述了一项由美国国立精神卫生研究所(NIMH)资助的研究方法,并展示了迄今为止该队列中的研究结果。

方法

我们使用大五人格量表中的神经质分量表来评估神经质,并采用了几种基于认知神经科学的方法来检验情绪控制能力。

结果

与27名未患抑郁症的老年对照受试者相比,33名老年抑郁症患者在状态焦虑、特质焦虑和神经质测量上得分更高。在基于实验神经科学的测量中,在情绪特征测试中,抑郁症患者比对照组认可更多负面词汇。此外,在一项情绪干扰测试中,我们发现了显著的组别与一致性效应,在该测试中,受试者被要求识别面部的情绪表达。同时忽略面部标注的“恐惧”或“快乐”字样。

结论

因此,在这项初步研究中,我们发现患抑郁症和未患抑郁症的老年人在神经质和情绪控制测量上存在显著差异。

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