专注于有丝分裂纺锤体。

Concentrating on the mitotic spindle.

作者信息

Maddox Paul S, Ladouceur Anne-Marie

机构信息

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

出版信息

J Cell Biol. 2015 Aug 31;210(5):691-3. doi: 10.1083/jcb.201508007.

DOI:10.1083/jcb.201508007

PMID:26323687

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4555814/

Abstract

In eukaryotes, the microtubule-based spindle drives chromosome segregation. In this issue, Schweizer et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506107) find that the spindle area is demarcated by a semipermeable organelle barrier. Molecular crowding, which is microtubule independent, causes the enrichment and/or retention of crucial factors in the spindle region. Their results add an important new feature to the models of how this structure assembles and is regulated.

摘要

在真核生物中，基于微管的纺锤体驱动染色体分离。在本期中，施韦泽等人（2015年；《细胞生物学杂志》http://dx.doi.org/10.1083/jcb.201506107）发现纺锤体区域由一个半透性细胞器屏障划定界限。分子拥挤现象独立于微管，导致关键因子在纺锤体区域富集和/或保留。他们的研究结果为该结构如何组装和受到调控的模型增添了一个重要的新特征。