Division of Endocrinology, Department of Puren Hospital, Wuhan University of Science and Technology, Wuhan, China.
Endocrine. 2011 Feb;39(1):69-74. doi: 10.1007/s12020-010-9413-6. Epub 2010 Nov 10.
Genetic variants of FTO and MC4R have been linked with obesity and T2DM in populations of Europeans. In this study, we have investigated the association of FTO rs9939609 and MC4R rs17782313 with obesity and T2DM in the Chinese population and analyzed the relationship between rs9939609 and rs17782313. 2351 individuals were recruited. We tested the rs9939609 and rs17782313 by sequences retrieval method. Clinical and biochemical characteristics were measured. The rs9939609 per-A allele and rs17782313 per-C allele increases of OR for obesity was 1.42 (95% CI 1.39-3.74) and 1.39 (95% CI 1.21-3.53).The genotypic OR for obesity was 1.92 (95% CI 1.81-4.67) for AA genotype, 1.71 (95% CI 1.47-4.54) for AT genotype, 1.87 (95% CI 1.72-4.00) for CC genotype, and 1.44 (95% CI 1.20-3.18) for CT genotype. BMI of participants carrying neither FTO nor MC4R risk allele was 25.9 ± 4.9, one risk allele was 26.4 ± 5.1, two risk alleles was 28.1 ± 5.5, and there or four risk alleles was 33.2 ± 6.3. We found no association between FTO and MC4R and the Chinese population with T2DM (P > 0.05). Our data support that the rs9939609 and rs17782313 are strongly associated with obesity and BMI. Their combined effects were significant in Chinese population. No association between FTO and MC4R and Chinese population with T2DM was found.
FTO 和 MC4R 的遗传变异与肥胖和 2 型糖尿病在欧洲人群中有关。在这项研究中，我们研究了 FTO rs9939609 和 MC4R rs17782313 与中国人肥胖和 2 型糖尿病的相关性，并分析了 rs9939609 与 rs17782313 之间的关系。共招募了 2351 人。我们采用序列检索法检测 rs9939609 和 rs17782313。测量了临床和生化特征。rs9939609 的每一个 A 等位基因和 rs17782313 的每一个 C 等位基因使肥胖的 OR 增加 1.42（95%CI 1.39-3.74）和 1.39（95%CI 1.21-3.53）。肥胖的基因型 OR 为 AA 基因型 1.92（95%CI 1.81-4.67），AT 基因型 1.71（95%CI 1.47-4.54），CC 基因型 1.87（95%CI 1.72-4.00），CT 基因型 1.44（95%CI 1.20-3.18）。既不携带 FTO 也不携带 MC4R 风险等位基因的参与者的 BMI 为 25.9±4.9，携带一个风险等位基因的参与者的 BMI 为 26.4±5.1，携带两个风险等位基因的参与者的 BMI 为 28.1±5.5，携带四个风险等位基因的参与者的 BMI 为 33.2±6.3。我们没有发现 FTO 和 MC4R 与中国 2 型糖尿病人群之间的关联（P>0.05）。我们的数据支持 rs9939609 和 rs17782313 与肥胖和 BMI 密切相关。它们在中国人群中的联合作用是显著的。没有发现 FTO 和 MC4R 与中国 2 型糖尿病人群之间的关联。
