Rodrigues Alex Rua, Trufelli Damila Cristina, Fonseca Fernando, de Paula Larissa Carvalho, Giglio Auro Del
Faculdade de Medicina do ABC, Santo André, Brazil.
Faculdade de Medicina do ABC, Santo André, Brazil
Am J Hosp Palliat Care. 2016 Dec;33(10):942-947. doi: 10.1177/1049909115603055. Epub 2015 Aug 30.
To assess which laboratory and clinical factors are associated with fatigue in patients with terminal cancer.
We evaluated 51 patients with advanced incurable solid tumors using the Chalder Fatigue Questionnaire (CFQ) and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale for fatigue; the Pittsburgh Sleep Quality Index (PSQI-BR) for sleep quality; the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression; the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire, Version 3.0 (QLQ C-30); and Functional Assessment of Cancer Therapy (FACT) for quality of life. We also analyzed several inflammatory markers and the modified Glasgow prognostic score (mGPS).
We observed severe fatigue in 19 (38%) patients (FACIT-F score >36). There was a significant correlation between fatigue as evaluated by the CFQ and quality of sleep and between the CFQ mental fatigue subscale scores and TNF-α level. When fatigue was evaluated using the FACIT-F scale, we observed a significant association between fatigue and anxiety/depression, quality of sleep, mGPS, and hemoglobin levels. Fatigue measured both with the CFQ and FACIT-F scale correlated with poor quality of life according to the EORTC QLQ C-30.
In patients with advanced cancer, fatigue is a common symptom associated with the presence of inflammation, poor quality of sleep, depression/anxiety, and poor quality of life.
评估哪些实验室和临床因素与晚期癌症患者的疲劳相关。
我们使用查尔德疲劳问卷（CFQ）和慢性病治疗功能评估-疲劳量表（FACIT-F）评估51例晚期不可治愈实体瘤患者的疲劳情况；使用匹兹堡睡眠质量指数（PSQI-BR）评估睡眠质量；使用医院焦虑抑郁量表（HADS）评估焦虑和抑郁；使用欧洲癌症研究与治疗组织（EORTC）核心生活质量问卷3.0版（QLQ C-30）和癌症治疗功能评估（FACT）评估生活质量。我们还分析了几种炎症标志物和改良格拉斯哥预后评分（mGPS）。
我们观察到19例（38%）患者存在严重疲劳（FACIT-F评分>36）。CFQ评估的疲劳与睡眠质量之间以及CFQ精神疲劳子量表评分与TNF-α水平之间存在显著相关性。当使用FACIT-F量表评估疲劳时，我们观察到疲劳与焦虑/抑郁、睡眠质量、mGPS和血红蛋白水平之间存在显著关联。根据EORTC QLQ C-30，CFQ和FACIT-F量表测量的疲劳均与生活质量差相关。
在晚期癌症患者中，疲劳是一种常见症状，与炎症、睡眠质量差、抑郁/焦虑和生活质量差有关。
