基底细胞癌不同阶段症状及影响的定性比较
A Qualitative Comparison of Symptoms and Impact of Varying Stages of Basal Cell Carcinoma.
作者信息
Steenrod Anna W, Smyth Emily Nash, Bush Elizabeth N, Chang Anne Lynn S, Arron Sarah T, Helfrich Yolanda R, Von Hoff Daniel D, Brail Leslie H, Coyne Karin S
机构信息
Evidera, Bethesda, MD, USA.
Early Phase Medical, Oncology, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
出版信息
Dermatol Ther (Heidelb). 2015 Sep;5(3):183-99. doi: 10.1007/s13555-015-0081-6. Epub 2015 Sep 1.
INTRODUCTION
Basal cell carcinoma (BCC) is the most common form of skin cancer; however, few data are available relating to patients' perspectives and experiences of this disease. This study explored the spectrum of BCC symptoms and their impact by disease stage to determine how BCC affects the overall health-related quality of life (HRQL) of patients.
METHODS
This study comprised a cross-sectional, qualitative approach involving telephone interviews with patients with BCC who had been divided into two groups: group 1 (G1), patients with stage 1, non-advanced BCC (and of superficial or nodular histology); and group 2 (G2), patients with locally advanced or metastatic BCC. Patients were recruited from three clinical sites in the USA based on a separate qualitative interview study (I4J-MC-HHBB [1.3]) over a 10-month period. Techniques in qualitative methodology were used by applying 'open-ended' questions and probing techniques intended to elicit patients' own description of their experiences with BCC. Telephone interviews lasted between 60 and 90 mins.
RESULTS
Thirty-four interviews were conducted (G1: N = 13; G2: N = 21). The majority of patients were aged either 55-64 years (32%, N = 11) or 76+ years (32%, N = 11) and were primarily male (82%, N = 28); most (75%, N = 24) patients were actively receiving BCC treatment. Both groups reported similar symptoms, with the most common being red lesions or open sores that failed to heal (41%, N = 14) and cancer-related stress (41%, N = 14). G2 reported more frequent and severe HRQL impact as a result of their cancer condition because most were affected in their daily activities (76%, N = 16) or emotional well-being (71%, N = 15). Cosmetic and functional impacts were relevant and important aspects of HRQL for both patient groups (G1: 31%, N = 4; G2: 48%, N = 10).
CONCLUSIONS
Patients with non-advanced or locally advanced and metastatic BCC experience disease-related symptoms that affect their HRQL, activities of daily living, emotional well-being, and social and/or leisure activities. Qualitative descriptions of patient experiences can help healthcare providers and caregivers better understand the impact of BCC from the patient perspective.
FUNDING
Eli Lilly and Company.
引言
基底细胞癌（BCC）是最常见的皮肤癌形式；然而，关于患者对这种疾病的看法和经历的数据很少。本研究探讨了基底细胞癌症状的范围及其在疾病不同阶段的影响，以确定基底细胞癌如何影响患者的整体健康相关生活质量（HRQL）。
方法
本研究采用横断面定性研究方法，通过电话访谈基底细胞癌患者，这些患者被分为两组：第1组（G1），1期非晚期基底细胞癌患者（组织学类型为浅表型或结节型）；第2组（G2），局部晚期或转移性基底细胞癌患者。根据一项单独的定性访谈研究（I4J-MC-HHBB [1.3]），在美国的三个临床地点，在10个月的时间里招募患者。采用定性研究方法中的技术，通过提出“开放式”问题和追问技巧，旨在引出患者对基底细胞癌经历的自身描述。电话访谈持续60至90分钟。
结果
共进行了34次访谈（G1：N = 13；G2：N = 21）。大多数患者年龄在55 - 64岁（32%，N = 11）或76岁及以上（32%，N = 11），主要为男性（82%，N = 28）；大多数（75%，N = 24）患者正在积极接受基底细胞癌治疗。两组报告的症状相似，最常见的是红色病变或不愈合的开放性溃疡（41%，N = 14）以及与癌症相关的压力（41%，N = 14）。由于癌症状况，G2组报告对HRQL的影响更频繁、更严重，因为大多数患者在日常活动（76%，N = 16）或情绪健康（71%，N = 15）方面受到影响。对于两组患者来说，美容和功能影响都是HRQL的相关且重要方面（G1：31%，N = 4；G2：48%，N = 10）。
结论
非晚期或局部晚期及转移性基底细胞癌患者会经历影响其HRQL、日常生活活动、情绪健康以及社交和/或休闲活动的疾病相关症状。对患者经历的定性描述有助于医疗服务提供者和护理人员从患者角度更好地理解基底细胞癌的影响。
资金来源
礼来公司。
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