Atli Abdullah, Bulut Mahmut, Bez Yasin, Kaplan İbrahim, Özdemir Pınar Güzel, Uysal Cem, Selçuk Hilal, Sir Aytekin
Department of Psychiatry, Dicle University, 21280, Diyarbakir, Turkey.
Department of Psychiatry, Marmara University, Istanbul, Turkey.
Eur Arch Psychiatry Clin Neurosci. 2016 Jun;266(4):329-36. doi: 10.1007/s00406-015-0638-5. Epub 2015 Sep 1.
The traumatic life events, including earthquakes, war, and interpersonal conflicts, cause a cascade of psychological and biological changes known as post-traumatic stress disorder (PTSD). Malondialdehyde (MDA) is a reliable marker of lipid peroxidation, and paraoxonase is a known antioxidant enzyme. The aims of this study were to investigate the relationship between earthquake trauma, PTSD effects on oxidative stress and the levels of serum paraoxonase 1 (PON1) enzyme activity, and levels of serum MDA. The study was carried out on three groups called: the PTSD group, the traumatized with earthquake exercise group, and healthy control group, which contained 32, 31, and 38 individuals, respectively. Serum MDA levels and PON1 enzyme activities from all participants were measured, and the results were compared across all groups. There were no significant differences between the PTSD patients and non-PTSD earthquake survivors in terms of the study variables. The mean PON1 enzyme activity from PTSD patients was significantly lower, while the mean MDA level was significantly higher than that of the healthy control group (p < 0.01 for both measurements). Similarly, earthquake survivors who did not develop PTSD showed higher MDA levels and lower PON1 activity when compared to healthy controls. However, the differences between these groups did not reach a statistically significant level. Increased MDA level and decreased PON1 activity measured in PTSD patients after earthquake and may suggest increased oxidative stress in these patients. The nonsignificant trends that are observed in lipid peroxidation markers of earthquake survivors may indicate higher impact of PTSD development on these markers than trauma itself. For example, PTSD diagnosis seems to add to the effect of trauma on serum MDA levels and PON1 enzyme activity. Thus, serum MDA levels and PON1 enzyme activity may serve as biochemical markers of PTSD diagnosis.
包括地震、战争和人际冲突在内的创伤性生活事件会引发一系列心理和生理变化，即创伤后应激障碍（PTSD）。丙二醛（MDA）是脂质过氧化的可靠标志物，对氧磷酶是一种已知的抗氧化酶。本研究的目的是调查地震创伤、PTSD对氧化应激的影响以及血清对氧磷酶1（PON1）酶活性水平和血清MDA水平之间的关系。该研究对三组人群进行：PTSD组、经历地震锻炼的受创伤组和健康对照组，分别包含32人、31人和38人。测量了所有参与者的血清MDA水平和PON1酶活性，并对所有组的结果进行了比较。在研究变量方面，PTSD患者和未患PTSD的地震幸存者之间没有显著差异。PTSD患者的平均PON1酶活性显著较低，而平均MDA水平显著高于健康对照组（两项测量的p值均<0.01）。同样，未患PTSD的地震幸存者与健康对照组相比，MDA水平较高，PON1活性较低。然而，这些组之间的差异未达到统计学显著水平。地震后PTSD患者中MDA水平升高和PON1活性降低，这可能表明这些患者的氧化应激增加。在地震幸存者的脂质过氧化标志物中观察到的不显著趋势可能表明，PTSD的发生对这些标志物的影响高于创伤本身。例如，PTSD诊断似乎会增加创伤对血清MDA水平和PON1酶活性的影响。因此，血清MDA水平和PON1酶活性可能作为PTSD诊断的生化标志物。
