Rosenberg S M, Luciano A A, Riddick D H
Fertil Steril. 1980 Jul;34(1):17-20. doi: 10.1016/s0015-0282(16)44831-4.
Three hundred and ninety-six patients were evaluated for primary and secondary infertility between December 1976 and May 1979 at a large referral center. Timed late luteal endometrial biopsies were routinely obtained as part of the work-up and were repeated for confirmation if subsequent menses did not occur within 2 days of the expected date. If both biopsies were abnormal, a diagnosis of luteal phase defect (LPD) was made and patients were treated with vaginal progesterone suppositories for a minimum of 6 months. LPD was discovered in 32 of 396 patients (8.1%); among those patients whose infertility was not complicated by other abnormalities, 9 of 13 conceived (70%) and 7 of 13 carried to term (54%). These data suggest an incidence higher than generally recognized and a very encouraging response to replacement therapy.
1976年12月至1979年5月期间，一家大型转诊中心对396例原发性和继发性不孕症患者进行了评估。作为检查的一部分，常规获取黄体晚期定时子宫内膜活检样本，如果随后的月经未在预期日期的2天内出现，则重复进行活检以确认。如果两次活检均异常，则诊断为黄体期缺陷（LPD），并给予患者阴道用黄体酮栓剂治疗至少6个月。在396例患者中有32例（8.1%）发现了LPD；在那些不孕症未合并其他异常的患者中，13例中有9例受孕（70%），13例中有7例足月分娩（54%）。这些数据表明其发病率高于普遍认知，且替代疗法的反应非常令人鼓舞。
