Tomlinson B, Smith C C, Ong A C, Graham B R, Betteridge D J, Prichard B N
Department of Clinical Pharmacology, University College, London, UK.
J Hypertens Suppl. 1989 Dec;7(6):S166-7. doi: 10.1097/00004872-198900076-00079.
Noradrenaline infusions were administered to 10 normal subjects through stepped doses and continued at 60 ng/kg per min for 2 h. Plasma noradrenaline rose from 1.7 +/- 0.3 to 7.7 +/- 0.7 pmol/ml and platelet noradrenaline rose from 2.1 +/- 0.2 to 2.6 +/- 0.2 pmol/mg protein. There was no change in plasma or platelet adrenaline. Platelet aggregation studies using ADP, adrenaline, collagen and thrombin as aggregants showed no overall change during the course of the infusion. Blood was sampled from a heated hand vein (hot box at 60 degrees C) to test the degree of arterialization. Plasma noradrenaline and blood pO2 and pCO2 showed intermediate levels at this sampling site compared with venous and true arterial values. Changes in platelet noradrenaline content can occur over 2 h when plasma levels are considerably increased by noradrenaline infusion. No change in platelet sensitivity to aggregation was observed. The heated hand vein did not provide true arterial levels of noradrenaline.
对10名正常受试者输注去甲肾上腺素，剂量逐步增加，并以每分钟60纳克/千克的速度持续输注2小时。血浆去甲肾上腺素从1.7±0.3皮摩尔/毫升升至7.7±0.7皮摩尔/毫升，血小板去甲肾上腺素从2.1±0.2皮摩尔/毫克蛋白升至2.6±0.2皮摩尔/毫克蛋白。血浆或血小板肾上腺素无变化。以二磷酸腺苷（ADP）、肾上腺素、胶原和凝血酶作为聚集剂进行的血小板聚集研究显示，在输注过程中总体无变化。从加热的手部静脉（60摄氏度的热箱）采集血液以检测动脉化程度。与静脉血和真正的动脉血值相比，该采样部位的血浆去甲肾上腺素、血氧分压（pO2）和血二氧化碳分压（pCO2）显示为中间水平。当通过去甲肾上腺素输注使血浆水平显著升高时，血小板去甲肾上腺素含量的变化可在2小时内发生。未观察到血小板对聚集的敏感性变化。加热的手部静脉未提供真正的动脉血去甲肾上腺素水平。
