Dürr Dorte Wiwe, Høyer Birgit Bjerre, Christensen Line Høgenhof, Pedersen Henning Sloth, Zinchuk Andrii, Jönsson Bo Ag, Lindh Christian H, Bonde Jens Peter, Toft Gunnar
Danish Ramazzini Center, Department of Occupational Medicine, Aarhus University Hospital, Nørrebrogade 44, build.2c, 8000 Aarhus C, Denmark.
Primary Health Care Clinic, Postbox 570, DK-3900 Nuuk, Greenland.
Reprod Toxicol. 2015 Dec;58:65-72. doi: 10.1016/j.reprotox.2015.08.005. Epub 2015 Sep 8.
This study examines associations between prenatal exposure to tobacco smoking and adverse behaviour in the offspring.
We included 1016 pregnant women from Greenland and Ukraine (526 from Greenland and 490 from Ukraine). Serum cotinine measurements were used to identify smoking pregnant women. When the children were from five to nine years of age, the parents assessed the child's behaviour using the Strength and Difficulties Questionnaire (SDQ).
Overall, smoking in pregnancy was not associated with a higher probability of adverse behaviour assessed by the total SDQ score. However, in the crude analysis smoking was associated with a higher mean difference of SDQ-total score. In Greenland the SDQ-total mean difference (MD) was (MD (95% CI)=1.31 points (0.42; 2.19)) and in Ukraine (MD (95% CI)=0.18 points (-1.2; 0.91)), whereas the adjusted mean differences were statistically non-significant.
In utero exposure to tobacco smoking was not associated with a significant higher risk of adverse behaviour in the offspring, but elevated risk of adverse behaviour among children prenatally exposed to smoking cannot be excluded.
本研究探讨孕期暴露于吸烟环境与后代不良行为之间的关联。
我们纳入了来自格陵兰和乌克兰的1016名孕妇（526名来自格陵兰，490名来自乌克兰）。通过血清可替宁测量来识别吸烟的孕妇。当孩子5至9岁时，父母使用长处与困难问卷（SDQ）对孩子的行为进行评估。
总体而言，孕期吸烟与SDQ总分评估的不良行为较高概率无关。然而，在粗分析中，吸烟与SDQ总分的较高平均差异相关。在格陵兰，SDQ总分平均差异（MD）为（MD（95%CI）=1.31分（0.42；2.19）），在乌克兰为（MD（95%CI）=0.18分（-1.2；0.91）），而调整后的平均差异无统计学意义。
子宫内暴露于吸烟环境与后代不良行为风险显著升高无关，但不能排除产前暴露于吸烟环境的儿童中不良行为风险升高的情况。
