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初次根治性膀胱切除术及一期尿流改道术后二期尿流改道的单中心经验

Single Center Experience with Secondary Urinary Diversion after Initial Radical Cystectomy and Primary Urinary Diversion.

作者信息

Hautmann Richard E, de Petriconi Robert, Schwarz Juliane, Volkmer Björn

机构信息

Department of Urology, University of Ulm, Ulm, Germany.

Department of Urology, University of Ulm, Ulm, Germany.

出版信息

J Urol. 2016 Feb;195(2):406-12. doi: 10.1016/j.juro.2015.08.086. Epub 2015 Aug 29.

DOI:10.1016/j.juro.2015.08.086
PMID:26327353
Abstract

PURPOSE

We evaluate the risk of a second urinary diversion in patients after radical cystectomy and urinary diversion.

MATERIALS AND METHODS

We retrospectively analyzed the records of 1,614 patients who underwent urinary diversion from January 1986 to March 2009. The primary diversion was neobladder in 71.9% of male patients and 42.3% of female patients, conduit in 17.6% and 38.6%, and ureterocutaneostomy in 9.5% and 12.5%, respectively. The outcome of interest was the need for a second urinary diversion.

RESULTS

A total of 51 second/third diversions in 48 patients formed the study population. Mean time from primary to second diversion was 57 months (range 0 to 286). The indication for cystectomy was oncologic in 28 patients and nononcologic in 23. Conversions were continent to continent (14), incontinent to continent (14), continent to incontinent (13) and incontinent to incontinent (10). Twelve patients had tumor recurrence impacting the initial diversion. In 8 patients the indication was abscess necrosis of the diversion or radiogenic damage. Six patients with renal failure required conversion. All patients with conversion from incontinent to continent had a strong desire to avoid a stoma. Four patients died perioperatively and short bowel syndrome developed in 1 patient.

CONCLUSIONS

A second urinary diversion was required in 1.8% of patients with bladder cancer with a heterogenous etiology vs 25% when the underlying disease was nononcologic. Only men with apex sparing cystectomy and women whose bladder had not been removed achieved excellent functional outcomes for later orthotopic reconstruction.

摘要

目的

我们评估了根治性膀胱切除术后行尿流改道患者再次进行尿流改道的风险。

材料与方法

我们回顾性分析了1986年1月至2009年3月期间1614例行尿流改道患者的记录。男性患者中71.9%的初次改道方式为新膀胱,女性患者为42.3%;导管造口术分别为17.6%和38.6%;输尿管皮肤造口术分别为9.5%和12.5%。感兴趣的结果是再次进行尿流改道的必要性。

结果

48例患者共进行了51次二次/三次改道,构成了研究人群。从初次改道到二次改道的平均时间为57个月(范围0至286个月)。膀胱切除的指征在28例患者中为肿瘤性,23例为非肿瘤性。改道类型包括从可控性到可控性(14例)、从不可控性到可控性(14例)、从可控性到不可控性(13例)和从不可控性到不可控性(10例)。12例患者出现肿瘤复发影响了初始改道。8例患者的指征是改道处脓肿坏死或放射性损伤。6例肾衰竭患者需要改道。所有从不可控性改道为可控性的患者都强烈希望避免造口。4例患者围手术期死亡,1例患者出现短肠综合征。

结论

膀胱癌患者中1.8%因病因各异需要再次进行尿流改道,而潜在疾病为非肿瘤性时这一比例为25%。只有保留膀胱尖部的男性膀胱切除术患者和未切除膀胱的女性患者在后期原位重建时获得了良好的功能结果。

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