Shams-White Marissa, Kelly Michael J, Gilhooly Cheryl, Liu Shanshan, Must Aviva, Parsons Susan K, Saltzman Edward, Zhang Fang Fang
Department of Nutrition Sciences, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Department of Pediatrics, Tufts University School of Medicine, Boston, MA, USA; Division of Pediatric Hematology/Oncology, The Floating Hospital for Children, Tufts Medical Center, Boston, MA, USA.
Appetite. 2016 Jan 1;96:1-6. doi: 10.1016/j.appet.2015.08.039. Epub 2015 Aug 30.
Cancer treatment can impact the hypothalamic-pituitary region of the developing brain, impairing appetite regulation and causing food craving in children who have survived cancer. We assessed food craving using a modified Food Craving Inventory in 22 survivors of pediatric acute lymphoblastic leukemia (ALL) and lymphoma (median age = 11.7 years) and evaluated its association with treatment exposure and changes in weight status over a one-year period. Mean total craving score was 2.1 (SD = 0.7). Survivors reported significantly higher mean craving score for fast-foods [2.6 (SD = 0.9)] than for sweets [2.1 (SD = 0.8)], carbohydrates [2.0 (SD = 0.6)], and fats [1.8 (SD = 0.7)] (all P values < 0.05). Results from multivariate linear regression indicated that survivors diagnosed at an older age (≥4.5 years) experienced higher frequencies of food craving than those diagnosed at a younger age (<4.5 years) (β = 0.88, 95% CI: 0.42, 1.34). Food craving, however, was not significantly associated with survivors' weight status over 12 months of follow-up. Food craving alone does not appear to explain the obesity risk in this sample of childhood cancer survivors. The role of food craving in shaping eating behavior and obesity risk needs to be further evaluated in a large cohort of childhood cancer survivors.
癌症治疗会影响发育中大脑的下丘脑 - 垂体区域，损害食欲调节，导致癌症幸存儿童出现食物渴望。我们使用改良的食物渴望量表对22名小儿急性淋巴细胞白血病（ALL）和淋巴瘤幸存者（中位年龄 = 11.7岁）的食物渴望情况进行了评估，并在一年时间内评估了其与治疗暴露及体重状况变化的关联。平均总渴望得分是2.1（标准差 = 0.7）。幸存者报告称，快餐的平均渴望得分[2.6（标准差 = 0.9）]显著高于甜食[2.1（标准差 = 0.8）]、碳水化合物[2.0（标准差 = 0.6）]和脂肪[1.8（标准差 = 0.7）]（所有P值 < 0.05）。多元线性回归结果表明，年龄较大（≥4.5岁）被诊断出的幸存者比年龄较小（<4.5岁）被诊断出的幸存者食物渴望频率更高（β = 0.88，95%置信区间：0.42，1.34）。然而，在12个月的随访中，食物渴望与幸存者的体重状况并无显著关联。仅食物渴望似乎并不能解释该儿童癌症幸存者样本中的肥胖风险。食物渴望在塑造饮食行为和肥胖风险方面的作用需要在一大群儿童癌症幸存者中进一步评估。
