Parati G, Ravogli A, Trazzi S, Villani A, Mutti E, Groppelli A, Mancia G
Cattedra di Semeiotica Medica, Università di Milano, Italy.
J Hypertens Suppl. 1989 Dec;7(6):S64-5. doi: 10.1097/00004872-198900076-00028.
We studied 15 normotensive offspring of hypertensive parents, comparing them with 15 normotensive controls matched for sex, body mass index and age. In the offspring, both parents were hypertensive, while in the controls, neither parent was hypertensive. Blood pressure was measured at rest, during a variety of laboratory stressors (mental arithmetic, mirror drawing test, hand grip and cold pressor test), and was also monitored for 24 h in ambulatory conditions (Spacelabs 5300 M, Richmond, Washington, USA). Resting mean and diastolic blood pressures were higher (P less than 0.05) in the subjects with parental hypertension than in those without. The mean blood pressure rise induced by the laboratory stressors was not significantly greater at any time in the subjects with hypertensive parents compared with controls. Twenty-four-hour systolic and mean blood pressures, however, were significantly higher (P less than 0.05) in the subjects with hypertensive parents than in the controls. Thus the higher office blood pressure shown in the prehypertensive stage by subjects with parental hypertension is not due to hypersensitivity to stress, but represents an early and permanent blood pressure elevation.
我们研究了15名高血压患者的血压正常的后代，并将他们与15名在性别、体重指数和年龄方面相匹配的血压正常的对照者进行比较。在后代组中，双亲均患有高血压，而在对照组中，双亲均无高血压。分别在静息状态下、各种实验室应激源（心算、镜像绘图测试、握力和冷加压测试）期间测量血压，并在动态条件下（使用美国华盛顿州里士满市太空实验室公司生产的5300M型设备）对血压进行24小时监测。有双亲患高血压的受试者静息时的平均血压和舒张压高于无双亲患高血压的受试者（P<0.05）。与对照组相比，有双亲患高血压的受试者在任何时候由实验室应激源诱发的平均血压升高均无显著差异。然而，有双亲患高血压的受试者24小时收缩压和平均血压显著高于对照组（P<0.05）。因此，有双亲患高血压的受试者在高血压前期阶段表现出的较高诊室血压并非由于对应激的高敏感性，而是代表了早期且持续的血压升高。
