Schwartz G L, Turner S T, Sing C F
Division of Hypertension, Mayo Clinic, Rochester, Minn. 55905.
Hypertension. 1992 Dec;20(6):834-40. doi: 10.1161/01.hyp.20.6.834.
We investigated whether blood pressures are higher in normotensive offspring of hypertensive parents than in normotensive offspring of normotensive parents outside the physician's office and, if so, whether these higher blood pressures are dependent on the level of dietary sodium intake. We compared 24-hour ambulatory blood pressure profiles between 11 normotensive sons of two hypertensive parents and 11 normotensive sons of two normotensive parents; profiles were recorded after 1 week of a low sodium diet (10 meq/day) and after 1 week of a high sodium diet (200 meq/day). The sons of hypertensive parents were on average 6 years older than the sons of normotensive parents (47 +/- 5 [SD] versus 41 +/- 4 years, p < 0.05). The shift from low to high sodium diet did not significantly change the magnitude of differences in office or ambulatory blood pressures between the groups (i.e., no group-by-diet interaction); thus, we assessed group effects by contrasting blood pressure means for each group pooled across diets. Age-adjusted office blood pressure was higher in sons of hypertensive parents than in sons of normotensive parents (116 +/- 7/80 +/- 6 versus 111 +/- 7/75 +/- 6 mm Hg; p = 0.020 for systolic and p = 0.003 for diastolic blood pressure).(ABSTRACT TRUNCATED AT 250 WORDS)
我们调查了在诊室以外的环境中，高血压患者的正常血压后代的血压是否高于正常血压父母的正常血压后代，如果是，这些较高的血压是否依赖于饮食中钠的摄入量。我们比较了两组人群的24小时动态血压：11名父母均为高血压患者的正常血压儿子，以及11名父母血压均正常的正常血压儿子；在低钠饮食（10毫当量/天）1周后和高钠饮食（200毫当量/天）1周后记录血压情况。高血压患者的儿子平均年龄比正常血压父母的儿子大6岁（47±5[标准差]岁对41±4岁，p<0.05）。从低钠饮食转变为高钠饮食，并未显著改变两组间诊室血压或动态血压的差异幅度（即无饮食分组交互作用）；因此，我们通过对比每组在两种饮食下的血压均值来评估分组效应。经年龄调整后，高血压患者儿子的诊室血压高于正常血压父母儿子的诊室血压（收缩压116±7/80±6对111±7/75±6毫米汞柱；收缩压p=0.020，舒张压p=0.003）。（摘要截选至250字）
