van Hooft I M, Grobbee D E, Waal-Manning H J, Hofman A
Department of Epidemiology, Erasmus University Medical School, Rotterdam, The Netherlands.
J Hypertens Suppl. 1989 Dec;7(6):S66-7. doi: 10.1097/00004872-198900076-00029.
The offspring of hypertensive parents in general show higher casual blood pressure levels during adolescence than the offspring of normotensive parents. Comparative ambulatory blood pressure measurements might reveal the stability and pattern of this difference during circadian blood pressure variation. We studied the 24-h ambulatory blood pressure (Space-Labs 90202 monitor, Redmond, Washington, USA) in youngsters with two hypertensive parents (high; n = 62), with one hypertensive parent (mixed; n = 51) and with no hypertensive parent (low; n = 42). The pattern for both systolic and diastolic blood pressure in the three groups ran parallel, with the high group continuously at a higher level. A clear difference in systolic blood pressure was observed during the day period (high minus low: 5.4 mmHg; 95% confidence range 2.5-8.3). Our data show that offspring of hypertensive parents differ in ambulatory blood pressure levels, but not in the circadian pattern, from the offspring of normotensive parents.
一般而言，高血压患者的子女在青春期的偶然血压水平高于血压正常者的子女。比较动态血压测量可能会揭示这种差异在昼夜血压变化期间的稳定性和模式。我们研究了父母双方均患有高血压的青少年（高风险组；n = 62）、父母一方患有高血压的青少年（混合组；n = 51）和父母均无高血压的青少年（低风险组；n = 42）的24小时动态血压（使用美国华盛顿州雷德蒙德市太空实验室90202监测仪）。三组的收缩压和舒张压模式平行，高风险组的血压持续处于较高水平。在白天时段观察到收缩压有明显差异（高风险组减去低风险组：5.4 mmHg；95%置信区间2.5 - 8.3）。我们的数据表明，高血压患者的子女与血压正常者的子女在动态血压水平上存在差异，但在昼夜模式上无差异。
