医护人员与住院患者相比的流感疫苗效力：一项2004 - 2009年病例对照、阴性对照的前瞻性研究。
Influenza vaccine effectiveness among healthcare workers in comparison to hospitalized patients: A 2004-2009 case-test, negative-control, prospective study.
作者信息
Vanhems P, Baghdadi Y, Roche S, Bénet T, Regis C, Lina B, Robert O, Voirin N, Ecochard R, Amour S
机构信息
a Service d'Hygiène; Epidémiologie et Prévention; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.
b Laboratoire d'Epidémiologie et Santé Publique; Université Claude Bernard Lyon 1; Université de Lyon ; Lyon , France.
出版信息
Hum Vaccin Immunother. 2016;12(2):485-90. doi: 10.1080/21645515.2015.1079677.
Abstract
The objective of this study was to calculate Vaccine Effectiveness (VE) in healthcare workers (HCW) and to compare VE between patients and HCW. A case-control investigation based on the prospective study was conducted between 2004 and 2009 in a teaching hospital. All HCW with influenza-like illness (ILI) from participating units (n = 24) were included, and vaccination status was characterized by interview. A total of 150 HCW presented ILI; 130 (87%) were female, 27 (18%) were positive for influenza, and 42 (28%) were vaccinated. Adjusted VE was 89% (95% CI 39 to 98). Among patients, adjusted VE was 42% (95% CI -39 to 76). The difference of VE (VEhcw - VEpat) was 46.15% (95% CI 2.41 to 144). The VE ratio (VEhcw / VEpat) was 2.09 (95% CI -1.60 to 134.17). Influenza VE differed between HCW and patients when the flu season was taken into account. This finding confirms the major impact of host determinants on influenza VE.
摘要
本研究的目的是计算医护人员（HCW）的疫苗效力（VE），并比较患者与医护人员之间的疫苗效力。2004年至2009年期间，在一家教学医院进行了一项基于前瞻性研究的病例对照调查。纳入了来自参与单位（n = 24）的所有患有流感样疾病（ILI）的医护人员，并通过访谈确定其疫苗接种状况。共有150名医护人员出现ILI；130名（87%）为女性，27名（18%）流感检测呈阳性，42名（28%）接种了疫苗。调整后的疫苗效力为89%（95%置信区间39%至98%）。在患者中，调整后的疫苗效力为42%（95%置信区间-39%至76%）。疫苗效力的差异（VEhcw - VEpat）为46.15%（95%置信区间2.41%至144%）。疫苗效力比值（VEhcw / VEpat）为2.09（95%置信区间-1.60至134.17）。考虑流感季节时，医护人员和患者的流感疫苗效力有所不同。这一发现证实了宿主因素对流感疫苗效力的重大影响。
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