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1
The European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2).欧洲2013 - 2014年I - MOVE多中心病例对照研究。针对甲型（H1N1）pdm09流感病毒，流感疫苗有效性表现出一致性且处于中等水平；而针对甲型（H3N2）流感病毒，不同国家的研究结果存在差异。
Vaccine. 2015 Jun 4;33(24):2813-22. doi: 10.1016/j.vaccine.2015.04.012. Epub 2015 Apr 28.
2
Influenza vaccine effectiveness in the United States during 2012-2013: variable protection by age and virus type.2012 - 2013年美国流感疫苗的有效性：按年龄和病毒类型划分的不同保护效果
J Infect Dis. 2015 May 15;211(10):1529-40. doi: 10.1093/infdis/jiu647. Epub 2014 Nov 18.
3
Efficacy of high-dose versus standard-dose influenza vaccine in older adults.大剂量与标准剂量流感疫苗在老年人中的效果比较。
N Engl J Med. 2014 Aug 14;371(7):635-45. doi: 10.1056/NEJMoa1315727.
4
Influenza vaccination coverage among patients and healthcare workers in a university hospital during the 2006-2007 influenza season.2006-2007 流感季节期间一所大学医院内患者和医护人员的流感疫苗接种率。
Vaccine. 2012 Dec 17;31(1):23-6. doi: 10.1016/j.vaccine.2012.10.059. Epub 2012 Oct 29.
5
Effectiveness of vaccine against pandemic influenza A/H1N1 among people with underlying chronic diseases: cohort study, Denmark, 2009-10.慢性病患者接种甲型 H1N1 流感大流行疫苗的效果：丹麦，2009-2010 年队列研究。
BMJ. 2011 Jan 25;344:d7901. doi: 10.1136/bmj.d7901.
6
Influenza vaccine effectiveness among adult patients in a University of Lyon hospital (2004-2009).里昂大学医院成人患者的流感疫苗效力（2004-2009 年）。
Vaccine. 2012 Jan 20;30(5):821-4. doi: 10.1016/j.vaccine.2011.11.033. Epub 2011 Dec 2.
7
Immune response to influenza vaccine in the elderly: association with nutritional and physical status.老年人对流感疫苗的免疫反应：与营养和身体状况的关系。
Geriatr Gerontol Int. 2011 Jan;11(1):63-8. doi: 10.1111/j.1447-0594.2010.00641.x. Epub 2010 Aug 25.
8
Methodologic issues regarding the use of three observational study designs to assess influenza vaccine effectiveness.关于使用三种观察性研究设计评估流感疫苗效力的方法学问题。
Int J Epidemiol. 2007 Jun;36(3):623-31. doi: 10.1093/ije/dym021. Epub 2007 Apr 2.
9
Prevention of antigenically drifted influenza by inactivated and live attenuated vaccines.通过灭活疫苗和减毒活疫苗预防抗原性漂移流感。
N Engl J Med. 2006 Dec 14;355(24):2513-22. doi: 10.1056/NEJMoa061850.
10
Global monitoring of influenza: potential contribution of national networks from a French perspective.全球流感监测：从法国视角看国家网络的潜在贡献
Expert Rev Anti Infect Ther. 2006 Jun;4(3):387-93. doi: 10.1586/14787210.4.3.387.

医护人员与住院患者相比的流感疫苗效力：一项2004 - 2009年病例对照、阴性对照的前瞻性研究。

Influenza vaccine effectiveness among healthcare workers in comparison to hospitalized patients: A 2004-2009 case-test, negative-control, prospective study.

作者信息

Vanhems P, Baghdadi Y, Roche S, Bénet T, Regis C, Lina B, Robert O, Voirin N, Ecochard R, Amour S

机构信息

a Service d'Hygiène; Epidémiologie et Prévention; Groupement hospitalier Edouard Herriot; Hospices Civils de Lyon ; Lyon , France.

b Laboratoire d'Epidémiologie et Santé Publique; Université Claude Bernard Lyon 1; Université de Lyon ; Lyon , France.

出版信息

Hum Vaccin Immunother. 2016;12(2):485-90. doi: 10.1080/21645515.2015.1079677.

DOI:10.1080/21645515.2015.1079677
PMID:26327520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5049739/
Abstract

The objective of this study was to calculate Vaccine Effectiveness (VE) in healthcare workers (HCW) and to compare VE between patients and HCW. A case-control investigation based on the prospective study was conducted between 2004 and 2009 in a teaching hospital. All HCW with influenza-like illness (ILI) from participating units (n = 24) were included, and vaccination status was characterized by interview. A total of 150 HCW presented ILI; 130 (87%) were female, 27 (18%) were positive for influenza, and 42 (28%) were vaccinated. Adjusted VE was 89% (95% CI 39 to 98). Among patients, adjusted VE was 42% (95% CI -39 to 76). The difference of VE (VEhcw - VEpat) was 46.15% (95% CI 2.41 to 144). The VE ratio (VEhcw / VEpat) was 2.09 (95% CI -1.60 to 134.17). Influenza VE differed between HCW and patients when the flu season was taken into account. This finding confirms the major impact of host determinants on influenza VE.

摘要

本研究的目的是计算医护人员（HCW）的疫苗效力（VE），并比较患者与医护人员之间的疫苗效力。2004年至2009年期间，在一家教学医院进行了一项基于前瞻性研究的病例对照调查。纳入了来自参与单位（n = 24）的所有患有流感样疾病（ILI）的医护人员，并通过访谈确定其疫苗接种状况。共有150名医护人员出现ILI；130名（87%）为女性，27名（18%）流感检测呈阳性，42名（28%）接种了疫苗。调整后的疫苗效力为89%（95%置信区间39%至98%）。在患者中，调整后的疫苗效力为42%（95%置信区间-39%至76%）。疫苗效力的差异（VEhcw - VEpat）为46.15%（95%置信区间2.41%至144%）。疫苗效力比值（VEhcw / VEpat）为2.09（95%置信区间-1.60至134.17）。考虑流感季节时，医护人员和患者的流感疫苗效力有所不同。这一发现证实了宿主因素对流感疫苗效力的重大影响。