Rajski Dariusz, Bobrowska Katarzyna, Pietrzak Bronisława, Wielgoś Mirosław, Kamiński Paweł
I Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.
Prz Menopauzalny. 2014 Jun;13(3):194-7. doi: 10.5114/pm.2014.43826. Epub 2014 Jun 30.
Endometrial polyps are a common focal endometrial pathology, with abnormal uterine bleeding (AUB) as a predominant symptom. Although the great majority of cases are benign, premalignancy or malignancy may develop within the polyp. The need for chronic immunosuppressive therapy in solid organ transplanted patients is associated with a significantly increased risk of malignant lesions.
Aim of the study was to evaluate the risk of endometrial polyps in solid organ transplanted women with abnormal uterine bleeding.
The retrospective analysis of 125 cases of AUB in allograft recipients and 200 consecutive cases of AUB in patients from the general population was performed. Pathological findings from dilatation and curettage were analyzed and compared between the groups.
Endometrial polyps were the only pathological findings in 12% and 21.5% of cases from the study and the control groups, respectively. In each of the groups, one case of endometrial cancer coexisted with an endometrial polyp. If cases of endometrial polyps coexisting with endometrial hyperplasia were taken into account, the rate of endometrial polyps was similar to that observed in the general population (20% vs. 21.5%, respectively).
Chronic immunosuppression, associated with an increased risk of malignancy, does not increase the risk of endometrial polyps among female graft recipients.
子宫内膜息肉是一种常见的局灶性子宫内膜病变，主要症状为异常子宫出血（AUB）。虽然绝大多数病例为良性，但息肉内可能发生癌前病变或恶性病变。实体器官移植患者需要长期免疫抑制治疗，这与恶性病变风险显著增加有关。
本研究旨在评估有异常子宫出血的实体器官移植女性患子宫内膜息肉的风险。
对125例同种异体移植受者的AUB病例和200例普通人群连续的AUB病例进行回顾性分析。分析并比较两组刮宫术的病理结果。
研究组和对照组中，分别有12%和21.5%的病例唯一的病理结果为子宫内膜息肉。每组中均有1例子宫内膜癌与子宫内膜息肉并存。若将子宫内膜息肉合并子宫内膜增生的病例考虑在内，子宫内膜息肉的发生率与普通人群相似（分别为20%和21.5%）。
与恶性病变风险增加相关的慢性免疫抑制，并未增加女性移植受者患子宫内膜息肉的风险。
