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Int J Oncol. 2025 May;66(5). doi: 10.3892/ijo.2025.5748. Epub 2025 May 9.
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本文引用的文献

1
Colorectal cancer: to stack or sequence therapy?结直肠癌：联合治疗还是序贯治疗？
J Natl Cancer Inst. 2015 May 9;107(5). doi: 10.1093/jnci/djv138. Print 2015 May.
2
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.LIN28与WNT信号通路协同作用，在小鼠和人类中引发侵袭性肠道和结肠直肠癌。
Genes Dev. 2015 May 15;29(10):1074-86. doi: 10.1101/gad.256693.114. Epub 2015 May 8.
3
Incidence of Interval Colorectal Cancer Among Inflammatory Bowel Disease Patients Undergoing Regular Colonoscopic Surveillance.炎症性肠病患者定期结肠镜监测的间隔期结直肠癌发病率。
Clin Gastroenterol Hepatol. 2015 Sep;13(9):1656-61. doi: 10.1016/j.cgh.2015.04.183. Epub 2015 May 6.
4
Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study.欧洲结直肠癌患者诊断前与世界癌症研究基金会/美国癌症研究协会指南的一致性及生存情况：一项队列研究
BMC Med. 2015 May 7;13:107. doi: 10.1186/s12916-015-0332-5.
5
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.快速增殖肿瘤细胞中高表达的基因作为结直肠癌治疗的新靶点。
Clin Cancer Res. 2015 Aug 15;21(16):3695-704. doi: 10.1158/1078-0432.CCR-14-2457. Epub 2015 May 5.
6
Next-Generation Sequencing Panels for the Diagnosis of Colorectal Cancer and Polyposis Syndromes: A Cost-Effectiveness Analysis.用于诊断结直肠癌和息肉病综合征的新一代测序面板：成本效益分析
J Clin Oncol. 2015 Jun 20;33(18):2084-91. doi: 10.1200/JCO.2014.59.3665. Epub 2015 May 4.
7
Circulating microRNAs: novel biomarkers for early detection of colorectal cancer.循环微RNA：用于早期检测结直肠癌的新型生物标志物。
Transl Res. 2015 Sep;166(3):219-24. doi: 10.1016/j.trsl.2015.04.007. Epub 2015 Apr 15.
8
A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer.碱基切除修复基因 NTHL1 中的胚系纯合突变导致腺瘤性息肉病和结直肠癌。
Nat Genet. 2015 Jun;47(6):668-71. doi: 10.1038/ng.3287. Epub 2015 May 4.
9
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.结直肠癌细胞系的分子图谱揭示了具有临床可操作性的激酶靶点。
Nat Commun. 2015 Apr 30;6:7002. doi: 10.1038/ncomms8002.
10
The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression.长链非编码RNA GAS5通过下调IGF-1R表达，增强吉非替尼对具有野生型EGFR的原发性EGFR酪氨酸激酶抑制剂耐药肺腺癌细胞的诱导细胞死亡作用。
J Hematol Oncol. 2015 Apr 29;8:43. doi: 10.1186/s13045-015-0140-6.

与结直肠癌进展发生相关的循环长链非编码RNA

Circulating lncRNAs associated with occurrence of colorectal cancer progression.

作者信息

Shi Jian, Li Xiaohua, Zhang Fan, Zhang Changxi, Guan Qinghai, Cao Xuefeng, Zhu Wentao, Zhang Xingyuan, Cheng Yu, Ou Kun, Chen Qiangpu, Hu Sanyuan

机构信息

Department of Hepatobiliary Surgery, Binzhou Medical University Hospital 661 Second Huanghe Road, Binzhou 256603, China ; Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.

Department of Pediatrics, Binzhou Medical University Hospital 661 Second Huanghe Road, Binzhou 256603, China.

出版信息

Am J Cancer Res. 2015 Jun 15;5(7):2258-65. eCollection 2015.

PMID:26328256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4548337/
Abstract

Screening for the potential biomarker of colorectal cancer (CRC) is necessary to improve the early detection. The aim of this study was to investigate the potential of circulating cell-free long non-coding RNAs (lncRNA) as biomarkers of CRC. In this study, we applied an lncRNA microarray to screen the potential biomarker for CRC with a multi-stage validation and risk score formula detection. We discovered three lncRNA, XLOC_006844, LOC152578 and XLOC_000303, which were up-regulated in CRC comparing with the cancer-free controls with the merged area under curve (AUC) in training set and validation set of 0.919 and 0.975. The three lncRNAs might be the potential biomarker for the tumorigenesis prediction of CRC in the future.

摘要

筛查结直肠癌（CRC）的潜在生物标志物对于提高早期检测至关重要。本研究的目的是探讨循环游离长链非编码RNA（lncRNA）作为CRC生物标志物的潜力。在本研究中，我们应用lncRNA微阵列通过多阶段验证和风险评分公式检测来筛查CRC的潜在生物标志物。我们发现了三种lncRNA，即XLOC_006844、LOC152578和XLOC_000303，与无癌对照相比，它们在CRC中上调，训练集和验证集的合并曲线下面积（AUC）分别为0.919和0.975。这三种lncRNA可能是未来CRC肿瘤发生预测的潜在生物标志物。