与结直肠癌进展发生相关的循环长链非编码RNA
Circulating lncRNAs associated with occurrence of colorectal cancer progression.
作者信息
Shi Jian, Li Xiaohua, Zhang Fan, Zhang Changxi, Guan Qinghai, Cao Xuefeng, Zhu Wentao, Zhang Xingyuan, Cheng Yu, Ou Kun, Chen Qiangpu, Hu Sanyuan
机构信息
Department of Hepatobiliary Surgery, Binzhou Medical University Hospital 661 Second Huanghe Road, Binzhou 256603, China ; Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Department of Pediatrics, Binzhou Medical University Hospital 661 Second Huanghe Road, Binzhou 256603, China.
出版信息
Am J Cancer Res. 2015 Jun 15;5(7):2258-65. eCollection 2015.
Abstract
Screening for the potential biomarker of colorectal cancer (CRC) is necessary to improve the early detection. The aim of this study was to investigate the potential of circulating cell-free long non-coding RNAs (lncRNA) as biomarkers of CRC. In this study, we applied an lncRNA microarray to screen the potential biomarker for CRC with a multi-stage validation and risk score formula detection. We discovered three lncRNA, XLOC_006844, LOC152578 and XLOC_000303, which were up-regulated in CRC comparing with the cancer-free controls with the merged area under curve (AUC) in training set and validation set of 0.919 and 0.975. The three lncRNAs might be the potential biomarker for the tumorigenesis prediction of CRC in the future.
摘要
筛查结直肠癌（CRC）的潜在生物标志物对于提高早期检测至关重要。本研究的目的是探讨循环游离长链非编码RNA（lncRNA）作为CRC生物标志物的潜力。在本研究中，我们应用lncRNA微阵列通过多阶段验证和风险评分公式检测来筛查CRC的潜在生物标志物。我们发现了三种lncRNA，即XLOC_006844、LOC152578和XLOC_000303，与无癌对照相比，它们在CRC中上调，训练集和验证集的合并曲线下面积（AUC）分别为0.919和0.975。这三种lncRNA可能是未来CRC肿瘤发生预测的潜在生物标志物。
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