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长链非编码 RNA XLOC_010588 的下调抑制结直肠癌细胞的侵袭和迁移。

Downregulation of the long non-coding RNA XLOC_010588 inhibits the invasion and migration of colorectal cancer.

机构信息

Department of Gastroenterology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Department of Pharmacology, School of Pharmaceutical Sciences, China Medical University, Shenyang, Liaoning 110122, P.R. China.

出版信息

Oncol Rep. 2018 Apr;39(4):1619-1630. doi: 10.3892/or.2018.6260. Epub 2018 Feb 12.

DOI:10.3892/or.2018.6260
PMID:29436686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5868398/
Abstract

Long non-coding RNAs (lncRNAs) have emer-ged as major players in many biological and pathological processes; however, investigation into the function of lncRNAs in the development and progression of cancer is in its infancy. Therefore, clarification of the mechanism by which cancer‑related lncRNAs function is of critical importance in research on tumorigenesis. It has been demonstrated that the lncRNA XLOC_010588 is expressed at a low level in cervical cancer, and that this has significant impact on the proliferation of cervical cancer cells. However, the expression pattern and functional roles of XLOC_010588 in colorectal cancer (CRC) remain unclear. In the present study, it was demonstrated that the expression of XLOC_010588 was significantly higher in CRC tissues when compared with that in adjacent normal tissues, and that XLOC_010588 was closely associated with metastasis and poor prognosis, thus indicating that XLOC_010588 may function as an oncogene. Additionally, downregulation of XLOC_010588 expression markedly inhibited the invasion and migration of CRC cells. Furthermore, it was demonstrated that XLOC_010588 may regulate the progression of CRC via the epithelial-mesenchymal transition (EMT) pathway. Notably, downregulation of XLOC_010588 inhibited the invasion and migration of CRC cells by regulating genes associated with EMT. Our findings revealed that XLOC_010588 may be considered as a novel potential diagnostic biomarker in CRC.

摘要

长链非编码 RNA（lncRNA）已成为许多生物和病理过程中的主要参与者；然而，lncRNA 在癌症发生和发展中的功能研究仍处于起步阶段。因此，阐明与癌症相关的 lncRNA 的作用机制对于肿瘤发生的研究至关重要。已经证明，lncRNA XLOC_010588 在宫颈癌中表达水平较低，这对宫颈癌细胞的增殖有重要影响。然而，XLOC_010588 在结直肠癌（CRC）中的表达模式和功能作用尚不清楚。在本研究中，XLOC_010588 在 CRC 组织中的表达明显高于相邻正常组织，XLOC_010588 与转移和预后不良密切相关，这表明 XLOC_010588 可能作为癌基因发挥作用。此外，下调 XLOC_010588 的表达显著抑制了 CRC 细胞的侵袭和迁移。此外，还证明 XLOC_010588 可能通过上皮-间充质转化（EMT）途径调节 CRC 的进展。值得注意的是，下调 XLOC_010588 通过调节 EMT 相关基因抑制 CRC 细胞的侵袭和迁移。我们的研究结果表明，XLOC_010588 可作为 CRC 的一种新的潜在诊断生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/afbc22893e01/OR-39-04-1619-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/37ac20892fbd/OR-39-04-1619-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/785f5b45022b/OR-39-04-1619-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/429cee50dc63/OR-39-04-1619-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/34daf0348f5d/OR-39-04-1619-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/0e2dc3a6983c/OR-39-04-1619-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/ac5ee3594cd7/OR-39-04-1619-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/c72e7543d892/OR-39-04-1619-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/d1dd68a2c06a/OR-39-04-1619-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/afbc22893e01/OR-39-04-1619-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/37ac20892fbd/OR-39-04-1619-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/785f5b45022b/OR-39-04-1619-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/429cee50dc63/OR-39-04-1619-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/34daf0348f5d/OR-39-04-1619-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/0e2dc3a6983c/OR-39-04-1619-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/ac5ee3594cd7/OR-39-04-1619-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/c72e7543d892/OR-39-04-1619-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/d1dd68a2c06a/OR-39-04-1619-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fca9/5868398/afbc22893e01/OR-39-04-1619-g08.jpg

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