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医疗专业人员对支持癌症生物样本库的看法:识别应对生物样本库陷阱的障碍

Health professionals' opinions on supporting a cancer biobank: identification of barriers to combat biobanking pitfalls.

作者信息

Caixeiro Nicole J, Byun Hei Lan, Descallar Joseph, Levesque Janelle V, de Souza Paul, Soon Lee Cheok

机构信息

Centre for Oncology Education and Research Translation (CONCERT), Liverpool, NSW, Australia.

Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia.

出版信息

Eur J Hum Genet. 2016 May;24(5):626-32. doi: 10.1038/ejhg.2015.191. Epub 2015 Sep 2.

Abstract

Although rarely acknowledged, a successful biobank is highly dependent on the support of the health professionals who assist the biobank in all aspects of its activities. In many cases, the lack of health professional support can be a limiting factor in the biobanking process of collecting and processing high-quality biospecimens. The aim of this study was to determine the attitudes of health professionals towards cancer biobanking. Using a 5-point Likert scale questionnaire, important aspects of biobanking, including accrual, quality, knowledge, responsiveness, impact, access, trust, governance and accreditation, were investigated. In total, 95 of 124 health and medical practitioners who were approached participated in this study (77% response rate). Health professionals in general supported the aims of biobanking with 56% of participants showing willingness to create a biobank and recruit donors (accrual), 85% understanding the importance in the storage and distribution of biospecimens (quality), 88% having an appreciation for the role of a biobank in furthering cancer research (knowledge), 70% showing awareness of the use of biospecimens in future research initiatives (responsiveness) and 73% demonstrating support for a biobank with proper control, authority and credibility measures in place (governance and accreditation). Overall, provided that proper information about the activities of the biobank and researcher access was transparent, health professionals were very willing to support cancer biobanking. These findings may assist in developing strategies for the establishment and maintenance of biobanks and aid the implementation of more effective policies and procedures to embed biobanking into routine hospital practices.

摘要

尽管很少有人承认,但一个成功的生物样本库高度依赖于健康专业人员的支持,他们在生物样本库活动的各个方面提供协助。在许多情况下,缺乏健康专业人员的支持可能是生物样本库收集和处理高质量生物样本过程中的一个限制因素。本研究的目的是确定健康专业人员对癌症生物样本库的态度。使用五点李克特量表问卷,对生物样本库的重要方面进行了调查,包括样本积累、质量、知识、响应能力、影响、获取、信任、治理和认证。总共124名被邀请的健康和医学从业者中有95人参与了本研究(回应率为77%)。总体而言,健康专业人员支持生物样本库的目标,56%的参与者表示愿意建立一个生物样本库并招募捐赠者(样本积累),85%的人理解生物样本存储和分发的重要性(质量),88%的人认识到生物样本库在推进癌症研究中的作用(知识),70%的人意识到生物样本在未来研究计划中的使用(响应能力),73%的人表示支持建立一个有适当控制、权威和可信度措施的生物样本库(治理和认证)。总体而言,只要生物样本库活动的相关信息和研究人员的获取是透明的,健康专业人员非常愿意支持癌症生物样本库。这些发现可能有助于制定生物样本库建立和维护的策略,并有助于实施更有效的政策和程序,将生物样本库纳入常规医院实践。

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