意大利吉兰-巴雷综合征多中心前瞻性发病率研究。ITANG研究。

A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study.

作者信息

Benedetti Maria Donata, Pugliatti Maura, D'Alessandro Roberto, Beghi Ettore, Chiò Adriano, Logroscino Giancarlo, Filippini Graziella, Galeotti Francesca, Massari Marco, Santuccio Carmela, Raschetti Roberto

机构信息

Neurology Unit, Policlinico Borgo Roma, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

出版信息

Neuroepidemiology. 2015;45(2):90-9. doi: 10.1159/000438752. Epub 2015 Aug 29.

DOI:10.1159/000438752

PMID:26329724

Abstract

BACKGROUND

To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS.

METHODS

All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions.

RESULTS

We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01).

CONCLUSIONS

In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

摘要

背景

为评估吉兰-巴雷综合征（GBS）的发病率，我们依托2010年在意大利7个地区建立的GBS研究意大利网络（ITANG）来分析流感疫苗接种与GBS之间的关联。

方法

2010年10月1日至2011年9月30日期间，所有年龄≥18岁、根据普遍接受的阿斯伯里诊断标准（1990年）出现提示GBS临床表现的个体均由ITANG神经科医生前瞻性地报告至一个集中数据库。通过电话调查，9名经过培训的访员对病例进行随访直至确诊，然后自出院起随访1年。在5个地区行政数据的支持下对病例报告进行了验证。

结果

在19,846,068名年龄≥18岁的人群中，我们发现365例符合GBS或其变异型定义的病例，年发病率为每10万人1.84例（95%可信区间1.65 - 2.03），男性为2.30例（95%可信区间1.99 - 2.60），女性为1.41例（95%可信区间1.18 - 1.64）。与参照月份（2011年9月）相比，2011年2月观察到一个高度显著的发病高峰（发病率比3.3:1，p < 0.01）。