金属蛋白酶组织抑制剂-1和-2与肥胖相关非酒精性脂肪性肝病：它们之间存在关联吗？

Tissue Inhibitors of Metalloproteinase-1 and 2 and Obesity Related Non-Alcoholic Fatty Liver Disease: Is There a Relationship.

作者信息

Abdelaziz Rokaya, Elbasel Mohamed, Esmat Serag, Essam Kareem, Abdelaaty Sahar

机构信息

Department of Internal Medicine, Cairo University, Cairo, Egypt.

出版信息

Digestion. 2015;92(3):130-7. doi: 10.1159/000439083. Epub 2015 Sep 1.

DOI:10.1159/000439083

PMID:26329758

Abstract

BACKGROUND/AIMS: Non-alcoholic fatty liver disease is a spectrum of clinical conditions, including simple steatosis and non-alcoholic steatohepatitis (NASH). The aim of the study is to evaluate the tissue inhibitors of metalloproteinase-1 and 2 (TIMPs) as noninvasive predictors of NASH.

METHODS

Three groups were included in the study. Obese patients (n = 30) with normal liver enzymes were included in group I and obese patients (n = 30) with elevated liver enzymes with liver biopsy-based diagnosis of NASH were included in group II. Age-matched subjects (n = 30) formed the control as group III. The lipid profile, liver enzyme levels and levels of TIMPs were compared among all the patients and subjects.

RESULTS

Comparison of groups I and II showed significantly elevated levels of TIMP-1 and TIMP-2 in group II as compared to group I (p < 0.05). Similarly, comparison between groups II and III showed significantly increased levels of TIMP-1 and TIMP-2 in group II as compared to group III (p < 0.05). TIMP-1 (sensitivity 96.7%, specificity 100%) and TIMP-2 (sensitivity 93.3%, specificity 100%) showed high accuracy in NASH diagnosis.

CONCLUSION

TIMP-1 and TIMP-2 may be considered noninvasive markers for the diagnosis of NASH.

摘要

背景/目的：非酒精性脂肪性肝病是一系列临床病症，包括单纯性脂肪肝和非酒精性脂肪性肝炎（NASH）。本研究的目的是评估金属蛋白酶组织抑制剂1和2（TIMPs）作为NASH的非侵入性预测指标。

方法

本研究纳入三组。第一组纳入肝功能正常的肥胖患者（n = 30），第二组纳入经肝活检诊断为NASH且肝功能酶升高的肥胖患者（n = 30）。年龄匹配的受试者（n = 30）作为第三组即对照组。比较所有患者和受试者的血脂谱、肝功能酶水平和TIMPs水平。

结果

第一组和第二组比较显示，与第一组相比，第二组的TIMP - 1和TIMP - 2水平显著升高（p < 0.05）。同样，第二组和第三组比较显示，与第三组相比，第二组的TIMP - 1和TIMP - 2水平显著升高（p < 0.05）。TIMP - 1（敏感性96.7%，特异性100%）和TIMP - 2（敏感性93.3%，特异性100%）在NASH诊断中显示出高准确性。