Moti Mahtab, Amini Leila, Mirhoseini Ardakani Soheila Sadat, Kamalzadeh Sara, Masoomikarimi Masoomeh, Jafarisani Moslem
Department of Midwifery, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Faculty of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Iran J Reprod Med. 2015 Jun;13(6):373-8.
Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes.
Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran.
In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples.
The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women.
These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.
多囊卵巢综合征（PCOS）是一种常见的不孕症疾病，影响着超过1亿女性。其特征为慢性无排卵、高雄激素血症和肥胖。PCOS还与氧化应激变化有关。
在此，我们旨在首次在伊朗调查患有PCOS的伊朗女性的抗氧化剂水平和氧化应激情况，将其作为心血管疾病的预测因素。
在这项横断面研究中，纳入了30名患有PCOS的女性和30名健康女性。从血液样本中测量C反应蛋白、血清胰岛素、晚期氧化蛋白产物和总抗氧化状态水平。
与健康女性相比，PCOS女性的血清胰岛素、C反应蛋白、晚期氧化蛋白产物水平显著升高，但PCOS女性的总抗氧化状态水平有所下降。
这些变化表明氧化应激促成了PCOS，而抗氧化剂的减少导致氧化产物增加，进而促成PCOS。
