Department of Oral and Maxillofacial Surgery, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, 660-702 Korea.
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714 Korea.
Biomater Res. 2014 Nov 24;18:18. doi: 10.1186/2055-7124-18-18. eCollection 2014.
For the effective bone regeneration with appropriate pathological/physiological properties, a variety of bone fillers have been adapted as a therapeutic treatment. However, the development of ideal bone fillers is still remained as a big challenge in clinical practice. The main aims of this study are i) fabrication of a highly porous PCL beads; and ii) the estimation of the potential use of the porous PCL beads as a bone filler through preliminary animal study.
The porous PCL beads with size range of 53 ~ 600 μm (425 ~ 500 μm dominantly) are fabricated by a spray/precipitation method using a double nozzle spray and PCL solution (in tetraglycol). The PCL beads show highly porous inner pore structure and the pores are interconnected with outer surface pores. For the preliminary animal study, we recognize that the porous PCL bead can induce the new bone formation from the outer surface of bone defect toward the bone marrow cavity through the bead matrix.
From the preliminary results, we can suggest that the highly porous PCL beads may be a promising candidate as a bone filler (scaffolding matrix) for the effective bone regeneration.
为了实现具有适当病理/生理特性的有效骨再生，已经开发了多种骨填充物作为治疗方法。然而，理想的骨填充物的开发在临床实践中仍然是一个巨大的挑战。本研究的主要目的是：i）制备具有高多孔性的 PCL 珠；ii）通过初步的动物研究评估多孔 PCL 珠作为骨填充物的潜在用途。
使用双喷嘴喷雾和 PCL 溶液（在四甘醇中）通过喷雾/沉淀法制备了尺寸范围为 53600μm（主要为 425500μm）的多孔 PCL 珠。PCL 珠具有高度多孔的内部孔结构，孔与外表面孔相互连通。对于初步的动物研究，我们认识到多孔 PCL 珠可以通过珠基质从骨缺损的外表面向骨髓腔诱导新骨形成。
从初步结果来看，我们可以认为高度多孔的 PCL 珠可能是一种有前途的骨填充物（支架基质），可有效促进骨再生。
