Nanotechnology and Advanced Materials (NATAM), Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor, 43500, Malaysia.
Electromechanical Technology, Abu Dhabi Polytechnic, Abu Dhabi, United Arab Emirates.
Int J Nanomedicine. 2019 Jul 24;14:5753-5783. doi: 10.2147/IJN.S192779. eCollection 2019.
Tissue engineering embraces the potential of recreating and replacing defective body parts by advancements in the medical field. Being a biocompatible nanomaterial with outstanding physical, chemical, optical, and biological properties, graphene-based materials were successfully employed in creating the perfect scaffold for a range of organs, starting from the skin through to the brain. Investigations on 2D and 3D tissue culture scaffolds incorporated with graphene or its derivatives have revealed the capability of this carbon material in mimicking in vivo environment. The porous morphology, great surface area, selective permeability of gases, excellent mechanical strength, good thermal and electrical conductivity, good optical properties, and biodegradability enable graphene materials to be the best component for scaffold engineering. Along with the apt microenvironment, this material was found to be efficient in differentiating stem cells into specific cell types. Furthermore, the scope of graphene nanomaterials in liver tissue engineering as a promising biomaterial is also discussed. This review critically looks into the unlimited potential of graphene-based nanomaterials in future tissue engineering and regenerative therapy.
组织工程通过医学领域的进步，具备了重塑和替换有缺陷的身体部位的潜力。基于石墨烯的材料是一种具有出色物理、化学、光学和生物特性的生物相容性纳米材料，已成功用于为从皮肤到大脑的各种器官制造理想的支架。对二维和三维组织培养支架中掺入石墨烯或其衍生物的研究表明，这种碳材料具有模拟体内环境的能力。多孔形态、大表面积、气体选择性渗透性、优异的机械强度、良好的热和电导率、良好的光学性能和生物降解性使石墨烯材料成为支架工程的最佳组件。与适当的微环境一起，这种材料被发现能够有效地将干细胞分化为特定的细胞类型。此外，还讨论了石墨烯纳米材料在肝脏组织工程作为一种有前途的生物材料中的应用。本文批判性地探讨了基于石墨烯的纳米材料在未来组织工程和再生治疗中的无限潜力。
