Tocci Giuliano, Ferrucci Andrea, Bruno Graziella, Mannarino Elmo, Nati Giulio, Trimarco Bruno, Volpe Massimo
1 Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, Rome, Italy ; 2 IRCCS Neuromed Institude, Pozzilli, IS, Italy ; 3 Department of Internal Medicine, University of Turin, Turin, Italy ; 4 Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy ; 5 Società Italiana Medici Generici (SIMG), Rome, Italy ; 6 Department of Clinical Medicine and Cardiovascular Sciences, University of Naples Federico II, Naples, Italy.
Cardiovasc Diagn Ther. 2015 Aug;5(4):271-9. doi: 10.3978/j.issn.2223-3652.2015.07.03.
Prevalence of metabolic syndrome (MS) in the clinical practice is still debated, due to different diagnostic criteria, target populations and clinical settings. Thus, the main purposes of the study were: (I) to evaluate prevalence of MS; (II) to estimate prevalence of additional cardiovascular (CV) risk factors and concomitant conditions in patients with MS followed by general practitioners (GPs) in Italy.
GPs from three different macro-areas were asked to evaluate the first and the last three outpatients, consecutively seen during 20 consecutive weeks in 2007, whatever the reason for clinical consultation. MS was defined according to Adult Treatment Panel (ATP) III definition. Clinical data were collected locally and centrally analysed.
The overall population sample included 4,513 outpatients, among which 1,574 (34.9%) from Regione Lazio, 1,498 (33.2%) from Regione Piemonte, and 1,441 (31.9%) from Regione Umbria. The population analysis included 4,418 (97.9%) adult outpatients [52.1% females, (mean age, 58.0±11.8 years); mean body mass index (BMI), 26.7±4.7 kg/m(2)]. MS was diagnosed in 1,456 (33.0%) outpatients. High-normal blood pressure (BP) was the most common risk factor for MS (n=1,382; 94.9%), followed by abdominal obesity (n=1,229; 84.4%), hypertriglyceridemia (n=1,032; 70.9%), abnormal fasting glucose (n=819; 56.3%) and low high-density lipoprotein (HDL) cholesterol levels (n=730; 50.1%).
Using this sample of outpatients followed by GPs in Italy, our study reports a relatively high prevalence of MS and a high prevalence of associated CV and metabolic risk factors in patients with than in those without MS.
由于诊断标准、目标人群和临床环境不同，代谢综合征（MS）在临床实践中的患病率仍存在争议。因此，本研究的主要目的是：（I）评估MS的患病率；（II）估计意大利全科医生（GP）随访的MS患者中其他心血管（CV）危险因素和伴随疾病的患病率。
邀请来自三个不同大区的全科医生评估2007年连续20周内连续就诊的首位和最后三位门诊患者，无论临床会诊原因如何。MS根据成人治疗小组（ATP）III定义进行定义。临床数据在当地收集并进行集中分析。
总体人群样本包括4513名门诊患者，其中来自拉齐奥大区的有1574名（34.9%），来自皮埃蒙特大区的有1498名（33.2%），来自翁布里亚大区的有1441名（31.9%）。人群分析包括4418名（97.9%）成年门诊患者[女性占52.1%，（平均年龄，58.0±11.8岁）；平均体重指数（BMI），为26.7±4.7kg/m²]。1456名（33.0%）门诊患者被诊断为MS。血压高值是MS最常见的危险因素（n = 1382；94.9%），其次是腹型肥胖（n = 1229；84.4%）、高甘油三酯血症（n = 1032；70.9%）、空腹血糖异常（n = 819；56.3%）和高密度脂蛋白（HDL）胆固醇水平低（n = 730；50.1%）。
通过对意大利全科医生随访的该门诊患者样本进行研究，我们发现MS患病率相对较高，且MS患者中相关CV和代谢危险因素的患病率高于非MS患者。
