Gava Giulia, Alvisi Stefania, Mancini Ilaria, Seracchioli Renato, Meriggiola Maria Cristina
Gynecology and Physiopathology of Human Reproduction, S. Orsola-Malpighi Hospital, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti, 9, 40138, Bologna, Italy.
Int Urogynecol J. 2019 Nov;30(11):1911-1917. doi: 10.1007/s00192-018-3840-y. Epub 2018 Dec 12.
Data regarding possible associations between metabolic syndrome (MS) and pelvic organ prolapse (POP) are scarce. The primary hypothesis was that the prevalence of MS and its components was higher in postmenopausal women with POP than in age-matched women without POP staged with the Pelvic Organ Prolapse Quantification system (POP-Q). The secondary aim of the study was to analyze the association between MS and its components with POP severity.
Presence of MS and its components [elevated triglycerides (TG), waist circumference, blood pressure, and fasting glucose (FG) and decreased high-density lipoprotein cholesterol (HDL-C)] were assessed in 122 women with POP (POP-Q stage I-IV) and 77 without (POP-Q 0). Fasting insulin resistance [homeostasis model assessment for fasting insulin resistance (HOMA-IR)] was also assessed.
TG levels, FG, and HOMA index were significantly higher in POP-Q stage I-IV compared with POP-Q 0 (p = 0.04, p = 0.0005 and p = 0.04); HDL-C was significantly reduced in POP-Q stage I-IV compared with POP-Q 0 (p = 0.0003). TG levels (p = 0.0315) were significantly higher in POP-Q stage III and IV vs. POP-Q 0; FG and HOMA-IR (p = 0.0015 and p = 0.0204) were significantly higher in POP-Q stage IV vs. POP-Q 0; HDL-C (p = 0.0047) was significantly lower in all stages vs. POP-Q 0. The prevalence of MS was different between groups (p = 0.04) and higher in POP-Q IV. Elevated TG [odds ratio (OR) 4.6, 95% confidence interval (CI) 1.5-9.3, p = 0.004] and reduced HDL-C (OR 2.0, 95% CI 1.1-3.7, p = 0.0241) significantly increased the risk of POP-Q stage ≥III.
MS and its components may be associated with POP. Elevated TG and reduced HDL-C are associated with POP severity.
关于代谢综合征（MS）与盆腔器官脱垂（POP）之间可能存在的关联的数据很少。主要假设是，采用盆腔器官脱垂定量系统（POP-Q）分期的绝经后POP女性中MS及其各组分的患病率高于年龄匹配的无POP女性。本研究的次要目的是分析MS及其组分与POP严重程度之间的关联。
对122例POP（POP-Q分期I-IV期）女性和77例无POP（POP-Q 0期）女性评估MS及其组分[甘油三酯（TG）升高、腰围、血压、空腹血糖（FG）升高以及高密度脂蛋白胆固醇（HDL-C）降低]的情况。还评估了空腹胰岛素抵抗[空腹胰岛素抵抗稳态模型评估（HOMA-IR）]。
与POP-Q 0期相比，POP-Q I-IV期的TG水平、FG和HOMA指数显著更高（p = 0.04、p = 0.0005和p = 0.04）；与POP-Q 0期相比，POP-Q I-IV期的HDL-C显著降低（p = 0.0003）。与POP-Q 0期相比，POP-Q III期和IV期的TG水平显著更高（p = 0.0315）；与POP-Q 0期相比，POP-Q IV期的FG和HOMA-IR显著更高（p = 0. ... ）。各阶段的HDL-C均显著低于POP-Q 0期（p = 0.0047）。两组间MS的患病率不同（p = 0.04），且在POP-Q IV期更高。TG升高[比值比（OR）4.6，95%置信区间（CI）1.5 - 9.3，p = 0.004]以及HDL-C降低（OR 2.0，95% CI 1.1 - 3.7，p = 0.0241）显著增加了POP-Q分期≥III期的风险。
MS及其组分可能与POP相关。TG升高和HDL-C降低与POP严重程度相关。 （注：原文中“p = 0.0047”后面的“p = 0.0015和p = 0.0204”处翻译时原文疑似有误，已按正确理解翻译，若实际不是该问题请根据正确情况调整。）
