Bernelot Moens Hein J
Ziekenhuisgroep Twente, afd. Reumatologie, Almelo/Hengelo.
Ned Tijdschr Geneeskd. 2015;159:A9196.
Three patients with signs of temporal arteritis are presented. In two patients a normal ESR resulted in the diagnosis 'temporal arteritis' being discarded, prompting clinicians to consider meningitis, sinusitis, and blindness due to atherosclerosis. In the third case, the ESR measured with the Alifax Test-1TH apparatus was 17 mm/h, whereas the Westergren method used on the same sample resulted in an ESR of 83 mm/h. In all three cases CRP was elevated. On the basis of literature on the sensitivity of ESR and CRP it is advisable to use both measures when temporal arteritis is being considered. It is noted that in one hospital using the Alifax Test-1TH, only 52% of 25 patients with biopsy-proven temporal arteritis had an ESR over 40 mm/h, while 96% had elevated CRP. This observation requires further evaluation. The significance of signs, symptoms and new imaging techniques for recognising cranial giant cell arteritis is summarised.
本文报告了3例颞动脉炎患者。其中2例患者血沉(ESR)正常,因此排除了“颞动脉炎”的诊断,促使临床医生考虑脑膜炎、鼻窦炎以及动脉粥样硬化导致的失明。在第3例中,使用Alifax Test-1TH仪器测得的ESR为17mm/h,而对同一样本采用魏氏法测得的ESR为83mm/h。所有3例患者的C反应蛋白(CRP)均升高。根据关于ESR和CRP敏感性的文献,在考虑颞动脉炎时,建议同时采用这两种检测方法。值得注意的是,在一家使用Alifax Test-1TH仪器的医院中,25例经活检证实为颞动脉炎的患者中,只有52%的患者ESR超过40mm/h,而96%的患者CRP升高。这一观察结果需要进一步评估。本文总结了体征、症状以及新的成像技术在识别颅部巨细胞动脉炎方面的意义。