Yuyucu Karabulut Y, Kankaya D, Şenel E, Dölek Y, Uslu A, Sertçelik A
Mersin University Faculty of Medicine, Department of Pathology, Mersin, Turkey -
G Ital Dermatol Venereol. 2015 Oct;150(5):495-9.
Scrotal calcinosis is a rare and benign condition characterized by multiple calcific deposits occurring in scrotum and formed as nodules and lumps within scrotal skin with any systemic metabolic disorder. The so-called idiopathic scrotal calcinosis does not appear to be idiopathic, but rather a process of dystrophic calcification of epidermal cysts. Histological examination shows calcium deposites with in the dermis that may be surrounded with histiocytes and an inflammatory giant cell reaction. The aim of this paper was to detect dystrophic calcification of epidermal cysts and to take attention to the incorrect terminology of "idiopathic calsification".
This is a two-centered study of scrotal calcinosis with 17 cases, on which clinical and histopathological examinations were conducted.
The patients we examined all had scrotal epidermoid cysts in varying stages of inflammation coexisted with scrotal calcinosis. Some cyts (52.9%) had intact epithelial walls, others (35.2%) showed rupture of their epithelial walls associated with the presence of keratin fibers and calcium granules in the surrounding dermis and all had naked calcium deposits lying in the dermis.
The spectrum of the changes that we experienced in the histology, coupled with the normal values in the biochemical profile, shore up the theory of dystrophic calcification of epithelial cysts. During the time first these cysts become inflamed than rupture in the and calcium depocytes replase with the cysts.
阴囊钙化症是一种罕见的良性疾病,其特征是阴囊内出现多个钙化沉积物,表现为阴囊皮肤内的结节和肿块,且无任何系统性代谢紊乱。所谓的特发性阴囊钙化症似乎并非特发性,而是表皮囊肿营养不良性钙化的过程。组织学检查显示真皮内有钙沉积,周围可能有组织细胞和炎性巨细胞反应。本文旨在检测表皮囊肿的营养不良性钙化,并关注“特发性钙化”这一错误术语。
这是一项对17例阴囊钙化症的双中心研究,对其进行了临床和组织病理学检查。
我们检查的患者均有处于不同炎症阶段的阴囊表皮样囊肿与阴囊钙化症并存。一些囊肿(52.9%)上皮壁完整,另一些(35.2%)上皮壁破裂,周围真皮内有角蛋白纤维和钙颗粒,且所有囊肿在真皮内均有裸露的钙沉积。
我们在组织学上观察到的一系列变化,加上生化指标的正常数值,支持了上皮囊肿营养不良性钙化的理论。首先这些囊肿发炎,然后破裂,钙沉积取代囊肿。