Dare A J, Axelsen R A
Department of Pathology, Princess Alexandra Hospital, Brisbane, Australia.
J Cutan Pathol. 1988 Jun;15(3):142-9. doi: 10.1111/j.1600-0560.1988.tb00534.x.
Scrotal calcinosis is a rare benign disorder considered idiopathic by most recent authors, although an origin from dystrophic calcification of epidermoid cysts has been proposed. In 3 of 4 cases which were otherwise typical of scrotal calcinosis, there was calcification of the contents of small cysts lined by stratified squamous epithelium. These structures were identified as eccrine duct milia because some of them communicated with eccrine ducts and there were ultrastructural features of eccrine duct differentiation in one case. The eccrine nature of the milia was confirmed using the immunoperoxidase technique for the demonstration of carcinoembryonic antigen (CEA) which serves as a marker of eccrine sweat glands. Since a transition could be seen between degenerating calcified milia and typical nodules, it appeared that the calcific deposits of scrotal calcinosis result from the breakdown of such lesions. Staining of deposits unassociated with cyst walls with the technique for the demonstration of CEA supported this conclusion. An advanced stage of evolution of the disease could account for the absence of visible cysts in many cases. We propose the term "hidrocalcinosis of the scrotum" for this distinctive form of cutaneous calcification.
阴囊钙化症是一种罕见的良性疾病，大多数现代学者认为其病因不明，尽管有人提出它起源于表皮样囊肿的营养不良性钙化。在4例典型的阴囊钙化症病例中，有3例可见由复层鳞状上皮衬里的小囊肿内容物发生钙化。这些结构被鉴定为小汗腺导管粟丘疹，因为其中一些与小汗腺导管相通，且在1例中具有小汗腺导管分化的超微结构特征。利用免疫过氧化物酶技术检测癌胚抗原（CEA）（其作为小汗腺的标志物）证实了粟丘疹的小汗腺性质。由于在退变的钙化粟丘疹和典型结节之间可见过渡状态，因此阴囊钙化症的钙沉积似乎是由这些病变的崩解所致。用检测CEA的技术对与囊肿壁无关的沉积物进行染色支持了这一结论。该疾病发展的晚期阶段可以解释在许多病例中看不到明显囊肿的原因。我们建议将这种独特的皮肤钙化形式称为“阴囊汗管钙化症”。
