Mehta S, Jain J, Mulye S
Department of Pediatrics Sri Aurobindo Medical College & PG Institute Indore, Madhya Pradesh, India.
Kathmandu Univ Med J (KUMJ). 2014 Oct-Dec;12(48):296-7. doi: 10.3126/kumj.v12i4.13738.
Celiac disease is an immune mediated disorder elicited by the ingestion of gluten in genetically susceptible person and associated with some HLA subtypes. It is characterized by chronic inflammation of small intestine associated with villous atrophy. Symptoms usually appear when weaning from breast milk is done and gluten is introduced in diet. Failures to thrive, chronic diarrhea, vomiting abdominal distension are usual symptoms. Celiac crisis is rare but well known complication of celiac disease presenting with various systemic and metabolic manifestations like hypokalemia, hyponatremia, shock and bleeding diathesis. Celiac crisis usually has some underlying precipitating factor and is more common in patient with noncompliance with gluten free diet. We report a case of 14 year and three months old female child, a known case of celiac disease having the poor compliance with gluten free diet, presenting in celiac crisis with shock, refractory hypokalemia and bleeding diathesis.
乳糜泻是一种由遗传易感人群摄入麸质引发的免疫介导性疾病，与某些人类白细胞抗原（HLA）亚型相关。其特征是小肠慢性炎症伴绒毛萎缩。症状通常在断奶并在饮食中引入麸质时出现。发育不良、慢性腹泻、呕吐、腹胀是常见症状。乳糜泻危象是乳糜泻罕见但广为人知的并发症，表现为各种全身和代谢表现，如低钾血症、低钠血症、休克和出血倾向。乳糜泻危象通常有一些潜在的诱发因素，在不遵守无麸质饮食的患者中更常见。我们报告一例14岁3个月大的女童，她是一名已知的乳糜泻患者，对无麸质饮食依从性差，因休克、难治性低钾血症和出血倾向而出现乳糜泻危象。
