Research Team "Histologistas", Interinstitutional Postgraduate Program "Health and Environmental Factors", Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Laboratory of Histology-Embryology, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Int J Mol Sci. 2024 Sep 20;25(18):10111. doi: 10.3390/ijms251810111.
According to the Institute of Environmental Sciences, endocrine-disrupting chemicals (EDCs) are "natural or human-made chemicals that may mimic, block, or interfere with the body's hormones, associated with a wide array of health issues", mainly in the endocrine system. Recent studies have discussed the potential contribution of EDCs as risk factors leading to diabetes mellitus type 1 (T1DM), through various cellular and molecular pathways.
The purpose of this study was to investigate the correlation between the EDCs and the development of T1DM.
Thus, a 5-year systematic review was conducted to bring light to this research question. Using the meta-analysis and systematic review guideline protocol, a PRISMA flow diagram was constructed and, using the keywords (diabetes mellitus type 1) AND (endocrine-disrupting chemicals) in the databases PubMed, Scopus and ScienceDirect, the relevant data was collected and extracted into tables. Quality assessment tools were employed to evaluate the quality of the content of each article retrieved.
Based on the data collected and extracted from both human and animal studies, an association was found between T1DM and certain EDCs, such as bisphenol A (BPA), bisphenol S (BPS), persistent organic pollutants (POPs), phthalates and dioxins. Moreover, based on the quality assessments performed, using the Newcastle-Ottawa Scale and ARRIVE quality assessment tool, the articles were considered of high quality and thus eligible to justify the correlation of the EDCs and the development of T1DM.
Based on the above study, the correlation can be justified; however, additional studies can be made focusing mainly on humans to understand further the pathophysiologic mechanism involved in this association.
根据环境科学研究所的说法，内分泌干扰化学物质（EDCs）是“可能模拟、阻断或干扰人体激素的天然或人为化学物质”，主要与内分泌系统的一系列健康问题有关。最近的研究讨论了 EDC 作为导致 1 型糖尿病（T1DM）的风险因素的潜在贡献，通过各种细胞和分子途径。
本研究旨在探讨 EDC 与 T1DM 发展之间的相关性。
因此，进行了为期 5 年的系统评价，以阐明这一研究问题。使用荟萃分析和系统评价指南方案，构建了 PRISMA 流程图，并使用数据库 PubMed、Scopus 和 ScienceDirect 中的关键词（1 型糖尿病）和（内分泌干扰化学物质），收集并提取相关数据到表格中。使用质量评估工具评估检索到的每篇文章的内容质量。
根据从人类和动物研究中收集和提取的数据，发现 T1DM 与某些 EDC 之间存在关联，例如双酚 A（BPA）、双酚 S（BPS）、持久性有机污染物（POPs）、邻苯二甲酸酯和二恶英。此外，根据使用纽卡斯尔-渥太华量表和 ARRIVE 质量评估工具进行的质量评估，这些文章被认为质量很高，因此有资格证明 EDC 与 T1DM 发展之间的相关性。
基于上述研究，可以证明这种相关性；然而，可以进行更多主要针对人类的研究，以进一步了解这种关联中涉及的病理生理机制。
