Kolecka Malgorzata, Ondreka Nele, Moritz Andreas, Kramer Martin, Schmidt Martin J
Department of Veterinary Clinical Sciences, Small Animal Clinic, Justus-Liebig-University, Frankfurter Straße 108, 35392, Giessen, Germany.
Acta Vet Scand. 2015 Sep 4;57(1):49. doi: 10.1186/s13028-015-0137-8.
Acetazolamide is recommended for the reduction of cerebrospinal fluid production in canine internal hydrocephalus. The efficacy of the drug in terms of alleviation of the clinical symptoms and the restoration of normal ventricular volume has not been documented. We hypothesize that acetazolamide inadequately improve clinical signs and has no effect on the ventricular volume. Six dogs with internal hydrocephalus underwent neurological examination and were examined by magnetic resonance imaging, on the day of the diagnosis, after treatment with acetazolamide directly before surgery, and 6 weeks after implantation of a vetriculo-peritoneal shunt due to lack of improvement after medical therapy with 10 mg/kg acetazolamide three times daily (TID). The ventricular volume in relation to the total brain volume was determined on each occasion. The changes in relative ventricular volume and of the neurological status were assessed and compared.
McNemar's test revealed no significant differences in clinical symptoms before and after medical treatment (P > 0.05). However, clinical symptoms changed significantly after surgical treatment (P = 0.001). The ventricle-brain ratio was not significantly changed after therapy with acetazolamide (P > 0.05); however, after subsequent shunt implantation, it was significantly reduced (P = 0.001).
Acetazolamide (10 mg/kg TID) showed no effects on clinical signs or ventricular volume in dogs with internal hydrocephalus. After subsequent ventriculo-peritoneal shunting, the dogs had a significantly reduced cerebral ventricular volume and five out of six dogs had no abnormal findings in neurological examination.
乙酰唑胺被推荐用于减少犬类交通性脑积水患者的脑脊液生成。该药物在缓解临床症状和恢复正常脑室容积方面的疗效尚未得到证实。我们假设乙酰唑胺不能充分改善临床症状，且对脑室容积无影响。六只患有交通性脑积水的犬在诊断当天、术前直接用乙酰唑胺治疗后以及因每天三次（TID）给予10mg/kg乙酰唑胺药物治疗后无改善而进行脑室 - 腹腔分流术植入6周后，接受了神经学检查和磁共振成像检查。每次均测定脑室容积与全脑容积的比值。评估并比较相对脑室容积和神经状态的变化。
McNemar检验显示药物治疗前后临床症状无显著差异（P>0.05）。然而，手术治疗后临床症状有显著变化（P = 0.001）。乙酰唑胺治疗后脑室 - 脑比率无显著变化（P>0.05）；然而，在随后的分流植入后，该比率显著降低（P = 0.001）。
乙酰唑胺（10mg/kg TID）对患有交通性脑积水的犬的临床症状或脑室容积无影响。在随后进行脑室 - 腹腔分流术后，犬的脑室容积显著减小，六只犬中有五只在神经学检查中无异常发现。
