乙型肝炎表面抗原血症：赞比亚献血者中的发病率及意义

Hepatitis B surface antigenaemia: incidence and significance in Zambian blood donors.

作者信息

Gill G V, Fimls A E

出版信息

Med J Zambia. 1979 Jun-Jul;13(3):52-4.

Abstract

Forty-eight (5.0%) of 966 healthy Zambian blood donors were positive for hepatitis B surface antigen (HBsAg) when tested by the turkey erythrocyte passive haemagglutination (TEPHA) method. Twenty-six were investigated in detail, but only one blood donor was found to have liver disease, and this was thought unlikely to be causally related to HBsAg (alcohol-induced fatty infiltration). It is recommended however, that blood donors should be screened for HBsAg. Positive individuals should be rejected but their serum tested for aspartate transaminase (AST), and, if elevated, a liver biopsy performed. This ideal policy is not practicable in all tropical hospitals.

摘要

在966名赞比亚健康献血者中，采用火鸡红细胞被动血凝试验（TEPHA）检测时，有48人（5.0%）乙肝表面抗原（HBsAg）呈阳性。对其中26人进行了详细调查，但仅发现1名献血者患有肝病，且认为这与HBsAg（酒精性脂肪浸润）不太可能存在因果关系。然而，建议对献血者进行HBsAg筛查。HBsAg阳性者应被拒绝献血，但需检测其血清中的天冬氨酸转氨酶（AST），若AST升高，则进行肝活检。这一理想政策在所有热带医院都不切实可行。