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持续性乙肝抗原血症的组织学和血清学研究

A histological and serological study of persistent hepatitis B antigenaemia.

作者信息

Pinn T G, Woodfield D G

出版信息

N Z Med J. 1983 Mar 9;96(727):153-6.

PMID:6572313
Abstract

A population of persistent hepatitis B antigen positive persons was investigated in north Taranaki. Over a period of three years, 0.17 percent of blood donors and 7.7 percent of patients investigated for acute infection, possibly hepatitis, had a positive test for hepatitis B surface antigen (HBsAg). Repeat testing was performed at approximately four months in 65 persons and 18 (28 percent) remained positive and of these 15 were males. Liver biopsy in 17 of these patients revealed chronic persistent hepatitis in 30 percent, non-specific changes in 11 percent and in the remainder no significant abnormalities were found. There was no correlation of histology with a wide variety of hepatitis B serological markers. Forty-seven percent of the persistent carriers were Maoris and this group may be more susceptible to chronic hepatitis B infection. Long term follow up of HBsAg carriers is recommended to ascertain the prognosis of this condition.

摘要

对塔拉纳基北部一群持续乙肝抗原阳性者进行了调查。在三年时间里,0.17%的献血者以及7.7%因急性感染(可能是肝炎)接受检查的患者乙肝表面抗原(HBsAg)检测呈阳性。65人在大约四个月后进行了重复检测,18人(28%)仍为阳性,其中15人为男性。这些患者中有17人接受了肝活检,结果显示30%为慢性持续性肝炎,11%为非特异性改变,其余未发现明显异常。组织学与多种乙肝血清学标志物之间没有相关性。47%的持续携带者是毛利人,该群体可能更易感染慢性乙肝。建议对HBsAg携带者进行长期随访以确定这种情况的预后。

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