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新维桑宁支架在慢性癫痫大鼠空间认知功能保存中的作用

Role of neovibsanin scaffold in preservation of spatial cognitive functions of rats with chronic epilepsy.

作者信息

Dong Li-Quan, Yan Li-Li, Pan Xu-Dong, Hu Jin-Hua, Zhang Jun-Wei

机构信息

Department of Neurology, The Affilated Hospital of Qingdao University Qingdao 266071, China.

Department of Hygiene, Women and Children's Hospital of Weihai City Weihai 264200, China.

出版信息

Int J Clin Exp Pathol. 2015 Jul 1;8(7):8692-8. eCollection 2015.

PMID:26339458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4555786/
Abstract

The effect of neovibsanin scaffold (NS) on the spatial cognitive functions of rats with lobal cerebrovascular hypoperfusion was investigated. Rats were divided into long-term memory (LTM) and short-term memory (STM) groups with 15 rats in each group. The groups were subdivided into 3 groups: control group comprised of 5 rats without surgery, untreated group of 5 rats left without treatment after 2OV, and NS treatment group with 5 rats receiving 5 mg/kg daily for 12 weeks of 2VO operation. NS-treatment caused a marked decrease in the escape latency time and total distance travelled in the treatment group compared to untreated group which was evident from the working memory test. The animals of treatment group also showed significant improvement over that of untreated group in maze test performance. Furthermore, NS treatment also resulted in significant improvement in the probe memory test performance in treatment group compared to untreated group. These findings suggest that NS exhibits therapeutic effect on the spatial cognitive preservation in rats with chronic epilepsy.

摘要

研究了新维桑宁支架（NS）对全脑性脑血管灌注不足大鼠空间认知功能的影响。将大鼠分为长期记忆（LTM）组和短期记忆（STM）组，每组15只。每组再细分为3组：对照组由5只未手术的大鼠组成，未治疗组为5只在2VO后未接受治疗的大鼠，NS治疗组为5只在2VO手术12周期间每天接受5 mg/kg NS治疗的大鼠。从工作记忆测试可知，与未治疗组相比，NS治疗组的逃避潜伏期时间和总移动距离显著缩短。治疗组动物在迷宫测试表现上也比未治疗组有显著改善。此外，与未治疗组相比，NS治疗组在探针记忆测试表现上也有显著改善。这些发现表明，NS对慢性癫痫大鼠的空间认知保留具有治疗作用。