Park Jong-Min, Jeong Migyeong, Kim Eun-Hee, Han Young-Min, Kwon Sung Hun, Hahm Ki-Baik
CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA Bio Complex, Seongnam 463-400, Republic of Korea.
Biomed Res Int. 2015;2015:712363. doi: 10.1155/2015/712363. Epub 2015 Aug 3.
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), commonly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been acknowledged as essential long-chain fatty acids imposing either optimal health promotion or the rescuing from chronic inflammatory diseases such as atherosclerosis, fatty liver, and various inflammatory gastrointestinal diseases. Recent studies dealing with EPA and DHA have sparked highest interests because detailed molecular mechanisms had been documented with the identification of its receptor, G protein coupled receptor, and GPR120. In this review article, we have described clear evidences showing that n-3 PUFAs could reduce various Helicobacter pylori- (H. pylori-) associated gastric diseases and extended to play even cancer preventive outcomes including H. pylori-associated gastric cancer by influencing multiple targets, including proliferation, survival, angiogenesis, inflammation, and metastasis. Since our previous studies strongly concluded that nonantimicrobial dietary approach for reducing inflammation, for instance, application of phytoceuticals, probiotics, natural products including Korean red ginseng, and walnut plentiful of n-3 PUFAs, might be prerequisite step for preventing H. pylori-associated gastric cancer as well as facilitating the rejuvenation of precancerous atrophic gastritis, these beneficial lipids can restore or modify inflammation-associated lipid distortion and correction of altered lipid rafts to send right signaling to maintain healthy stomach even after chronic H. pylori infection.
ω-3多不饱和脂肪酸（n-3 PUFAs），通常为二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），已被公认为必需的长链脂肪酸，对促进最佳健康或从慢性炎症性疾病（如动脉粥样硬化、脂肪肝和各种炎症性胃肠疾病）中恢复具有重要作用。最近关于EPA和DHA的研究引发了极大的兴趣，因为随着其受体G蛋白偶联受体和GPR120的鉴定，详细的分子机制已被记录下来。在这篇综述文章中，我们描述了明确的证据，表明n-3 PUFAs可以减少各种幽门螺杆菌（H. pylori）相关的胃部疾病，甚至通过影响多个靶点（包括增殖、存活、血管生成、炎症和转移）发挥癌症预防作用，包括预防H. pylori相关的胃癌。由于我们之前的研究强烈得出结论，减少炎症的非抗菌饮食方法，例如应用植物药、益生菌、包括韩国红参在内的天然产物以及富含n-3 PUFAs的核桃，可能是预防H. pylori相关胃癌以及促进癌前萎缩性胃炎恢复活力的先决步骤，这些有益的脂质可以恢复或改变与炎症相关的脂质畸变，并纠正改变的脂筏，以便在慢性H. pylori感染后仍能发送正确的信号来维持胃部健康。
