Cardoso Taiane de Azevedo, Campos Mondin Thaíse, Reyes Amanda Neumann, Zeni Cristian Patrick, Souza Luciano Dias de Mattos, da Silva Ricardo Azevedo, Jansen Karen
*Universidade Católica de Pelotas-Programa de Pós-Graduação em Saúde e Comportamento, Pelotas, Rio Grande do Sul, Brazil; and †Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, TX.
J Nerv Ment Dis. 2015 Oct;203(10):792-7. doi: 10.1097/NMD.0000000000000369.
The objective was to evaluate the effect of psychoeducation on biological rhythm and in the reduction of depressive, anxious, and manic symptoms at 12 months' follow-up. This was a randomized clinical trial with young adults aged 18 to 29 years, diagnosed with bipolar disorder. Biological rhythm was assessed with the Biological Rhythm Interview Assessment in Neuropsychiatry (BRIAN). Participants were randomized for combined intervention (psychoeducation plus medication) or treatment-as-usual (medication alone). The sample consisted of 61 patients (29 TAU; 32 combined intervention). Although it failed to separate by a marginal difference, the combined intervention seems to be more effective than TAU in relation to improvement of depressive symptoms at post-intervention (p = 0.074) and regulation of sleep/social domain at 6 months' follow-up (p = 0.057). Improvement of depressive symptoms as well as regulation of sleep and social activities are known to prevent episode onset and thus improve long-term outcomes.
目的是评估心理教育对生物节律的影响，以及在12个月随访时减轻抑郁、焦虑和躁狂症状的效果。这是一项针对18至29岁被诊断为双相情感障碍的年轻成年人的随机临床试验。生物节律通过神经精神病学中的生物节律访谈评估（BRIAN）进行评估。参与者被随机分配接受联合干预（心理教育加药物治疗）或常规治疗（仅药物治疗）。样本包括61名患者（29名接受常规治疗；32名接受联合干预）。尽管未能以微弱差异区分，但联合干预在干预后改善抑郁症状（p = 0.074）和6个月随访时调节睡眠/社交领域方面似乎比常规治疗更有效（p = 0.057）。已知改善抑郁症状以及调节睡眠和社交活动可预防发作，从而改善长期预后。
