Lim Cherry, Blacksell Stuart D, Laongnualpanich Achara, Kantipong Pacharee, Day Nicholas P J, Paris Daniel H, Limmathurotsakul Direk
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
J Clin Microbiol. 2015 Nov;53(11):3663-6. doi: 10.1128/JCM.01680-15. Epub 2015 Sep 9.
We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ≥1:3,200 in an admission sample or of a ≥4-fold rise to ≥1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%).
我们使用贝叶斯潜在类别模型确定了恙虫病间接免疫荧光试验中入院和恢复期样本的最佳临界滴度。入院样本中临界滴度≥1:3200或恢复期样本中滴度升高≥4倍至≥1:3200时，准确性最高（敏感性为81.6%；特异性为100%）。
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