Schneider Sabrina M, Kielstein Jan T, Braverman Jennifer, Novak Marta
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
Semin Nephrol. 2015 Jul;35(4):304-10. doi: 10.1016/j.semnephrol.2015.06.002.
Cognitive dysfunction is a common symptom in patients with chronic kidney disease (CKD). In this review, we highlight the clinical relevance of cognitive impairment in patients with CKD. After a summary of the different pathophysiological components of this frequently overlooked clinical condition, we summarize and evaluate the available neurocognitive tests and reflect on their utility in everyday clinical practice. Finally, we identify future areas of research and allude to the fact that inclusion of cognitive function testing in routine clinical care of patients with CKD could be cost effective by reducing nonadherence to medication and improving quality of life, and even survival.
认知功能障碍是慢性肾脏病（CKD）患者的常见症状。在本综述中，我们强调了CKD患者认知障碍的临床相关性。在总结了这种常被忽视的临床状况的不同病理生理成分后，我们总结并评估了现有的神经认知测试，并思考了它们在日常临床实践中的效用。最后，我们确定了未来的研究领域，并暗示在CKD患者的常规临床护理中纳入认知功能测试可能具有成本效益，因为它可以减少药物治疗的不依从性，提高生活质量，甚至延长生存期。
