维生素D受体FokI、BsmI和TaqI基因多态性与类风湿关节炎易感性的Meta分析
Vitamin D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis : A meta-analysis.
作者信息
Song G G, Bae S-C, Lee Y H
机构信息
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, 136-705, Seoul, Korea.
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
出版信息
Z Rheumatol. 2016 Apr;75(3):322-9. doi: 10.1007/s00393-015-1581-6.
OBJECTIVE
The aim of this study was to explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA).
METHODS
Meta-analyses were conducted on the associations between the VDR FokI, BsmI, and TaqI polymorphisms and RA.
RESULTS
A total of seven studies were considered in the meta-analysis, involving a total of 923 patients and 912 controls. Meta-analysis of the VDR FokI polymorphism showed no association between RA and the F allele in the entire studied cohort (odds ratio, OR = 1.1740, 95 % confidence interval, CI = 0.994-1.387, p = 0.059). However, stratification by ethnicity revealed a significant association between the F allele and RA in Europeans (OR = 1.402, 95 % CI = 1.126-1.746, p = 0.003). Furthermore, an association was found between RA and the VDR FokI polymorphism using both the dominant model and homozygote contrast. Meta-analysis revealed no association between RA and the VDR BsmI B and TaqI T polymorphisms in Europeans (OR for the B allele = 1.065, 95 % CI = 0.911-1.245, p = 0.427; OR for the T allele = 1.065, 95 % CI = 0.834-1.361, p = 0.613).
CONCLUSION
This meta-analysis suggests that the VDR FokI polymorphism is associated with susceptibility to RA in European populations.
目的
本研究旨在探讨维生素D受体（VDR）基因多态性与类风湿关节炎（RA）易感性之间是否存在关联。
方法
对VDR FokI、BsmI和TaqI基因多态性与RA之间的关联进行荟萃分析。
结果
荟萃分析共纳入7项研究，涉及923例患者和912例对照。对VDR FokI基因多态性的荟萃分析显示，在整个研究队列中，RA与F等位基因之间无关联（优势比，OR = 1.1740，95%置信区间，CI = 0.994 - 1.387，p = 0.059）。然而，按种族分层显示，在欧洲人中F等位基因与RA之间存在显著关联（OR = 1.402，95% CI = 1.126 - 1.746，p = 0.003）。此外，使用显性模型和纯合子对比均发现RA与VDR FokI基因多态性之间存在关联。荟萃分析显示，在欧洲人中RA与VDR BsmI B和TaqI T基因多态性之间无关联（B等位基因的OR = 1.065，95% CI = 0.911 - 1.245，p = 0.427；T等位基因的OR = 1.065，95% CI = 0.834 - 1.361，p = 0.613）。
结论
该荟萃分析表明，VDR FokI基因多态性与欧洲人群RA易感性相关。
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