Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Mol Biol Rep. 2012 Jun;39(6):6471-8. doi: 10.1007/s11033-012-1466-6.
The aim of this study was to explore whether vitamin D receptor (VDR) polymorphisms confer susceptibility to psoriasis. Meta-analyses were conducted on the associations between the VDR ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis. Nine relevant studies on VDR polymorphisms and psoriasis were included in this meta-analysis, which involved 742 psoriasis patients and 715 controls. Meta-analysis indicated an association between the VDR ApaI A allele and psoriasis in Turkish studies (OR = 0.684, 95% CI = 0.475–0.985, p = 0.041). Meta-analysis indicated an association between the BsmI B allele and psoriasis in Asians (OR = 0.636, 95% CI = 0.411–0.984, p = 0.041), and showed a significant association between the FF and ff genotypes of the FokI polymorphism and psoriasis in all study subjects and in Turkish studies (OR = 2.028, 95% CI = 1.194–3.446, p = 0.009; OR = 3.582, 95% CI = 1.602–8.009, p = 0.002). This meta-analysis suggests that the VDR ApaI polymorphism confers susceptibility to psoriasis in the Turkish population. In addition, associations were found between the BsmI polymorphism and susceptibility to psoriasis in Asians and between the Fok I polymorphism and psoriasis in the Turkish population.
本研究旨在探讨维生素 D 受体 (VDR) 多态性是否与银屑病易感性相关。我们对 VDR ApaI、TaqI、BsmI 和 FokI 多态性与银屑病的相关性进行了荟萃分析。该荟萃分析纳入了 9 项关于 VDR 多态性与银屑病的研究，共涉及 742 例银屑病患者和 715 例对照。荟萃分析结果显示，土耳其人群中 VDR ApaI A 等位基因与银屑病相关（OR = 0.684，95%CI = 0.475–0.985，p = 0.041）。亚洲人群中 BsmI B 等位基因与银屑病相关（OR = 0.636，95%CI = 0.411–0.984，p = 0.041），FokI 多态性 FF 和 ff 基因型与所有研究对象和土耳其人群中的银屑病显著相关（OR = 2.028，95%CI = 1.194–3.446，p = 0.009；OR = 3.582，95%CI = 1.602–8.009，p = 0.002）。本荟萃分析提示 VDR ApaI 多态性与土耳其人群中银屑病易感性相关。此外，还发现 BsmI 多态性与亚洲人群中银屑病易感性相关，FokI 多态性与土耳其人群中银屑病相关。
