[Significance of the serum level of Cu, Zn, Mn, Cr and Ni in acute leukemia].

Serum Cu and Ni increase, while serum Zn and Mn decrease in acute leukemia patients. The results of this study showed that there is correlation between the change of the level of serum Ni and the condition of the patient. Higher level of serum Ni in patients with acute leukemia indicates inefficient chemotherapy and poor prognosis. The results suggest that the level of serum Ni may be used as an in acute leukemia. Increase of serum Ni with simultaneous decrease of serum Mn may be an instinctive reflection in acute leukemia.