遗传风险评分可预测晚年认知障碍。
Genetic Risk Score Predicts Late-Life Cognitive Impairment.
作者信息
Wollam Mariegold E, Weinstein Andrea M, Saxton Judith A, Morrow Lisa, Snitz Beth, Fowler Nicole R, Suever Erickson Barbara L, Roecklein Kathryn A, Erickson Kirk I
机构信息
Department of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USA.
Department of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USA ; Center for the Neural Basis of Cognition, University of Pittsburgh, 4400 Fifth Avenue, Suite 115, Pittsburgh, PA 15213, USA.
出版信息
J Aging Res. 2015;2015:267062. doi: 10.1155/2015/267062. Epub 2015 Aug 23.
Introduction. A family history of Alzheimer's disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired). Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P = .013) when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms.
引言。阿尔茨海默病家族史是其发病的一个重要风险因素，但与拥有多个风险等位基因相关的遗传风险仍知之甚少。方法。在95名老年人样本（平均年龄 = 75.1岁，64.2%为女性）中，我们基于脑源性神经营养因子（BDNF）、儿茶酚-O-甲基转移酶（COMT）和载脂蛋白E（APOE）中风险等位基因的累积构建了一个遗传风险评分。通过神经心理学评估并达成共识确定认知状态（44名未受损，51名受损）。进行逻辑回归以确定遗传风险评分是否能预测超出与每个基因相关的认知障碍。结果。当在模型中将个体基因多态性作为协变量纳入时，遗传风险评分增加与认知障碍风险增加近4倍相关（比值比 = 3.824，P = 0.013）。讨论。与个体多态性相比，结合多种遗传影响的风险评分在预测晚年认知障碍方面可能更有用。
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