From the *College of Medicine, University of Arizona, Tucson; †Department of Dermatology, University of California, San Francisco; ‡Department of Medicine, University of Arizona, Tucson; and §Palo Alto Foundation Medical Group, Mountain View, CA.
Dermatitis. 2015 Sep-Oct;26(5):224-9. doi: 10.1097/DER.0000000000000132.
The repeated open application test (ROAT) provides useful information regarding allergens in suspected cases of allergic contact dermatitis; however, standardized methodology has not been established.
The aim of this study was to assess how ROAT is used in clinical and research settings.
We distributed a survey regarding ROAT practice to the American Contact Dermatitis Society and conducted a literature review of ROAT utilization in research.
A total of 67 American Contact Dermatitis Society members participated in the survey. Respondents most frequently recommend application of leave-on products twice daily (46.0%) and rinse-off products once daily (43.5%). The most commonly used anatomical sites include the forearm (38.7%) and antecubital fossa (32.3%). Most respondents continue ROAT for 1 (49.2%) or 2 weeks (31.7%). Literature review of 32 studies (26 leave-on, 6 rinse-off) revealed that application frequency is most common at twice daily for both leave-on (96.2%) and rinse-off (50.0%) products. The most common anatomical site is the forearm (62.5%), with an overall study duration of 3 to 4 weeks (65.6%).
When comparing ROAT clinical and research practice, the majority trend was consistent for leave-on product application frequency and anatomical site, but not for rinse-off product application frequency, or overall duration. Further research is needed to determine best practice recommendations.
重复开放应用测试（ROAT）在疑似过敏性接触性皮炎的情况下提供了有关过敏原的有用信息；然而，尚未建立标准化的方法。
本研究旨在评估 ROAT 在临床和研究环境中的使用情况。
我们向美国接触性皮炎学会（American Contact Dermatitis Society）分发了一份关于 ROAT 实践的调查，并对 ROAT 在研究中的应用进行了文献回顾。
共有 67 名美国接触性皮炎学会成员参与了调查。受访者最常推荐每日两次涂抹（46.0%）和每日一次冲洗（43.5%）的留用产品。最常使用的解剖部位包括前臂（38.7%）和肘前窝（32.3%）。大多数受访者继续 ROAT 治疗 1 周（49.2%）或 2 周（31.7%）。对 32 项研究（26 项留用，6 项冲洗）的文献回顾显示，留用产品的应用频率最常见为每日两次（96.2%）和冲洗产品（50.0%）。最常见的解剖部位是前臂（62.5%），研究总持续时间为 3 至 4 周（65.6%）。
在比较 ROAT 临床和研究实践时，留用产品应用频率和解剖部位的大多数趋势是一致的，但冲洗产品的应用频率和总体持续时间不一致。需要进一步研究以确定最佳实践建议。
